Single-cell multi-omics technologies have revolutionized cancer research by allowing us to
examine individual cells at a molecular level. Unlike traditional bulk omics approaches …

The pathogenesis of coronary heart disease is a highly complex process, with lipid
metabolism disorders being closely linked to its development. Therefore, this paper …

Long non-coding RNAs (lncRNAs) are known to perform important regulatory functions in
lipid metabolism. Large-scale whole-genome sequencing (WGS) studies and new statistical …

Background The relationship between mitochondrial DNA copy number (mtDNA CN) and
cardiovascular disease remains elusive. Methods and Results We performed cross …

Abstract Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) play critical
roles in human health. Prior genome-wide association studies (GWAS) of n-3 and n-6 …

Objectives The purpose of this study was to investigate whether there is a causal
relationship between periodontitis and breast cancer by Mendelian randomization analysis …

Aim Genome‐wide association studies (GWAS) have identified multiple susceptibility loci
associated with insulin resistance (IR)‐relevant phenotypes. However, the genes …

Genetic variation contributes greatly to LDL cholesterol (LDL-C) levels and coronary artery
disease risk. By combining analysis of rare coding variants from the UK Biobank and …

Genome-wide association studies (GWASs) have uncovered numerous trait-associated loci
across the human genome, most of which are located in noncoding regions, making …

Better understanding of the mechanisms underlying cardiovascular disease (CVD) is critical
for improving prediction, diagnosis, and treatment of these conditions affecting millions of …