The process of senescence (aging) is predominantly determined by the action of wild-type
genes. For most organisms, this does not reflect any adaptive function that senescence …

Stem cell systems regulate tissue development and maintenance. The germline stem cell
system is essential for animal reproduction, controlling both the timing and number of …

Aging (senescence) is characterized by the development of numerous pathologies, some of
which limit lifespan. Key to understanding aging is discovery of the mechanisms (etiologies) …

Hallmarks of cancer and hallmarks of aging - PMC Back to Top Skip to main content NIH
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The nematode Caenorhabditis elegans exhibits rapid senescence that is promoted by the
insulin/IGF-1 signalling (IIS) pathway via regulated processes that are poorly understood. IIS …

In post-reproductive C. elegans, destructive somatic biomass repurposing supports
production of yolk which, it was recently shown, is vented and can serve as a foodstuff for …

Maximum lifespan differs greatly between species, indicating that the process of senescence
is largely genetically determined. Senescence evolves in part due to antagonistic pleiotropy …

Both individuals taking rapamycin, an anti-aging drug, and those not taking it will ultimately
succumb to age-related diseases. However, the former, if administered disease-oriented …

Almost all papers on aging start with the statement that aging is functional decline caused by
accumulation of molecular damage. In contrast, according to the hyperfunction theory, aging …

The aging process in semelparous and iteroparous species is different, but how different?
Death in semelparous organisms (eg, Pacific salmon) results from suicidal reproductive …