Targeting receptor complexes: a new dimension in drug discovery
MI Rosenbaum, LS Clemmensen, DS Bredt… - Nature Reviews Drug …, 2020 - nature.com
Targeting receptor proteins, such as ligand-gated ion channels and G protein-coupled
receptors, has directly enabled the discovery of most drugs developed to modulate receptor …
receptors, has directly enabled the discovery of most drugs developed to modulate receptor …
PDZ domains as drug targets
NR Christensen, J Čalyševa… - Advanced …, 2019 - Wiley Online Library
Protein–protein interactions within protein networks shape the human interactome, which
often is promoted by specialized protein interaction modules, such as the postsynaptic …
often is promoted by specialized protein interaction modules, such as the postsynaptic …
Cell-Permeable and Plasma-Stable Peptidomimetic Inhibitors of the Postsynaptic Density-95/N-Methyl-d-Aspartate Receptor Interaction
A Bach, JNN Eildal, N Stuhr-Hansen… - Journal of Medicinal …, 2011 - ACS Publications
The protein− protein interaction between the NMDA receptor and its intracellular scaffolding
protein, PSD-95, is a potential target for treating ischemic brain diseases, neuropathic pain …
protein, PSD-95, is a potential target for treating ischemic brain diseases, neuropathic pain …
Ligand binding by PDZ domains
The postsynaptic density protein‐95/disks large/zonula occludens‐1 (PDZ) protein domain
family is one of the most common protein–protein interaction modules in mammalian cells …
family is one of the most common protein–protein interaction modules in mammalian cells …
A high‐affinity, bivalent PDZ domain inhibitor complexes PICK 1 to alleviate neuropathic pain
NR Christensen, M De Luca, MB Lever… - EMBO molecular …, 2020 - embopress.org
Maladaptive plasticity involving increased expression of AMPA‐type glutamate receptors is
involved in several pathologies, including neuropathic pain, but direct inhibition of AMPAR s …
involved in several pathologies, including neuropathic pain, but direct inhibition of AMPAR s …
Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission
HM Maric, TJ Hausrat, F Neubert, NO Dalby… - Nature chemical …, 2017 - nature.com
Abstract γ-Aminobutyric acid type A and glycine receptors are the major mediators of fast
synaptic inhibition in the human central nervous system and are established drug targets …
synaptic inhibition in the human central nervous system and are established drug targets …
Structure function relations in PDZ-domain-containing proteins: Implications for protein networks in cellular signalling
GP Manjunath, PL Ramanujam, S Galande - Journal of biosciences, 2018 - Springer
Protein scaffolds as essential backbones for organization of supramolecular signalling
complexes are a recurrent theme in several model systems. Scaffold proteins preferentially …
complexes are a recurrent theme in several model systems. Scaffold proteins preferentially …
The scaffold protein PICK1 as a target in chronic pain
Well-tolerated and effective drugs for treating chronic pain conditions are urgently needed.
Most chronic pain patients are not effectively relieved from their pain and suffer from …
Most chronic pain patients are not effectively relieved from their pain and suffer from …
Protein-protein interactions and aggregation inhibitors in Alzheimer's disease
Background: Alzheimer's Disease (AD), a multifaceted disorder, involves complex
pathophysiology and plethora of protein-protein interactions. Thus such interactions can be …
pathophysiology and plethora of protein-protein interactions. Thus such interactions can be …
Phosphorus oxychloride as an efficient coupling reagent for the synthesis of esters, amides and peptides under mild conditions
A mild method is described for the conversion of carboxylic acids into esters, amides, as well
as peptides without racemization through carboxyl activation by the reagent combination of …
as peptides without racemization through carboxyl activation by the reagent combination of …