Androgen production, being important for male fertility, is mainly accomplished by the Leydig
cells from the interstitial compartment of the testis. Testosterone plays a critical role in testis …

Genistin is a type of isoflavone glycoside and has a broad range of health benefits. It is
found in a variety of dietary plants, such as soybean, kudzu (Japanese arrowroot), and other …

Phthalate esters, commonly used as plasticizers, show anti‐androgenic activity and cause
male reproductive malformation in experimental animals. However, the effects of prenatal …

The presence of bisphenol A (BPA) in consumer products has raised concerns about
potential adverse effects on reproductive health. Testicular Leydig cells are the predominant …

Isoflavones are a group of secondary metabolites found in plants belonging to the class of
phytoestrogens. These, because they have a chemical structure similar to the endogenous …

Abstract Ginger [Zingiber officinale Roscoe (Zingiberaceae)] and turmeric [Curcuma longa
Linn (Zingiberaceae)] rhizomes have been reportedly used in folk medicine for the treatment …

Previous research has focused on the beneficial effects of soy and its active ingredients,
isoflavones. For instance, soy consumption has been associated with lower cardiovascular …

The present study investigated if Aflatoxin B 1 (AFB 1), a potent and naturally occurring
mycotoxin, interferes with the steroidogenic pathway in rat Leydig cells. Testicular Leydig …

Testicular Leydig cells are the predominant source of the male sex steroid hormone
testosterone (T), which is required to maintain male fertility. There is now growing evidence …

Encouraged by the potential health benefits of higher dietary intake of substances with
beneficial properties, the use of supplements containing these compounds has increased …