Metabolomics as a powerful tool for diagnostic, pronostic and drug intervention analysis in COVID-19

C Bruzzone, R Conde, N Embade, JM Mato… - Frontiers in Molecular …, 2023 - frontiersin.org
COVID-19 currently represents one of the major health challenges worldwide. Albeit its
infectious character, with onset affectation mainly at the respiratory track, it is clear that the …

The effect of polyunsaturated fatty acids on the severity and mortality of COVID patients: a systematic review

A Mazidimoradi, E Alemzadeh, E Alemzadeh… - Life Sciences, 2022 - Elsevier
Background Covid-19 mortality is largely associated with a severe increase in inflammatory
cytokines and polyunsaturated fatty acids (PUFAs) play an important role in modulating …

Machine learning and semi-targeted lipidomics identify distinct serum lipid signatures in hospitalized COVID-19-positive and COVID-19-negative patients

H Castañé, S Iftimie, G Baiges-Gaya… - Metabolism, 2022 - Elsevier
Background Lipids are involved in the interaction between viral infection and the host
metabolic and immunological responses. Several studies comparing the lipidome of COVID …

A global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants

SE Farley, JE Kyle, HC Leier, LM Bramer… - Nature …, 2022 - nature.com
A comprehensive understanding of host dependency factors for SARS-CoV-2 remains
elusive. Here, we map alterations in host lipids following SARS-CoV-2 infection using …

Dynamic modulations of sphingolipids and glycerophospholipids in COVID‐19

M Kurano, K Okamoto, D Jubishi… - Clinical and …, 2022 - Wiley Online Library
Background A heterogeneous clinical phenotype is a characteristic of coronavirus disease
2019 (COVID‐19). Therefore, investigating biomarkers associated with disease severity is …

Untargeted analysis in post-COVID-19 patients reveals dysregulated lipid pathways two years after recovery

Y López-Hernández, JJ Oropeza-Valdez… - Frontiers in molecular …, 2023 - frontiersin.org
Introduction: Similar to what it has been reported with preceding viral epidemics (such as
MERS, SARS, or influenza), SARS-CoV-2 infection is also affecting the human …

Deep phenotyping of the lipidomic response in COVID‐19 and non‐COVID‐19 sepsis

H Meng, A Sengupta, E Ricciotti… - Clinical and …, 2023 - Wiley Online Library
Background Lipids may influence cellular penetrance by viral pathogens and the immune
response that they evoke. We deeply phenotyped the lipidomic response to SARs‐CoV‐2 …

Lipid metabolism of plasma-derived small extracellular vesicles in COVID-19 convalescent patients

W Xiao, Q Huang, P Luo, X Tan, H Xia, S Wang… - Scientific Reports, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19), which affects multiple organs, is
causing an unprecedented global public health crisis. Most COVID-19 patients recover …

Visible-light-activated aziridination reaction enables simultaneous resolving of C= C bond location and the sn-position isomers in lipids

Q Wan, Y Xiao, G Feng, X Dong, W Nie, M Gao… - Chinese Chemical …, 2024 - Elsevier
There is a close relationship between the biological functions of lipids and their structures,
and various isomers greatly increases the complexity of lipid structures. The C= C bond …

Integrated metabolic and inflammatory signatures associated with severity of, fatality of, and recovery from COVID-19

LG Gardinassi, CP Servian, GS Lima… - Microbiology …, 2023 - Am Soc Microbiol
Severe manifestations of coronavirus disease 2019 (COVID-19) and mortality have been
associated with physiological alterations that provide insights into the pathogenesis of the …