[HTML][HTML] Understanding glycosylation: Regulation through the metabolic flux of precursor pathways
Glycosylation is how proteins and lipids are modified with complex carbohydrates known as
glycans. The post-translational modification of proteins with glycans is not a template-driven …
glycans. The post-translational modification of proteins with glycans is not a template-driven …
[HTML][HTML] Nucleotide sugar transporter SLC35 family structure and function
The covalent attachment of sugars to growing glycan chains is heavily reliant on a specific
family of solute transporters (SLC35), the nucleotide sugar transporters (NSTs) that connect …
family of solute transporters (SLC35), the nucleotide sugar transporters (NSTs) that connect …
In vivo evidence for GDP-fucose transport in the absence of transporter SLC35C1 and putative transporter SLC35C2
Slc35c1 encodes an antiporter that transports GDP-fucose into the Golgi and returns GMP to
the cytoplasm. The closely related gene Slc35c2 encodes a putative GDP-fucose transporter …
the cytoplasm. The closely related gene Slc35c2 encodes a putative GDP-fucose transporter …
Novel insights into the prognosis and immunological value of the SLC35A (solute carrier 35A) family genes in human breast cancer
According to statistics 2020, female breast cancer (BRCA) became the most commonly
diagnosed malignancy worldwide. Prognosis of BRCA patients is still poor, especially in …
diagnosed malignancy worldwide. Prognosis of BRCA patients is still poor, especially in …
Examination of differential glycoprotein preferences of N-acetylglucosaminyltransferase-IV isozymes a and b
The N-glycans attached to proteins contain various GlcNAc branches, the aberrant formation
of which correlates with various diseases. N-Acetylglucosaminyltransferase-IVa (GnT-IVa or …
of which correlates with various diseases. N-Acetylglucosaminyltransferase-IVa (GnT-IVa or …
Nucleotide sugar transporter SLC35A2 is involved in promoting hepatocellular carcinoma metastasis by regulating cellular glycosylation
H Cheng, S Wang, D Gao, K Yu, H Chen, Y Huang… - Cellular Oncology, 2023 - Springer
Purpose Recently, aberrant glycosylation has been recognized to be relate to malignant
behaviors of cancer and outcomes of patients with various cancers. SLC35A2 plays an …
behaviors of cancer and outcomes of patients with various cancers. SLC35A2 plays an …
Biosynthesis of GlcNAc-rich N-and O-glycans in the Golgi apparatus does not require the nucleotide sugar transporter SLC35A3
B Szulc, P Sosicka, D Maszczak-Seneczko… - Journal of Biological …, 2020 - ASBMB
Nucleotide sugar transporters, encoded by the SLC35 gene family, deliver nucleotide
sugars throughout the cell for various glycosyltransferase-catalyzed glycosylation reactions …
sugars throughout the cell for various glycosyltransferase-catalyzed glycosylation reactions …
Translation of genome to glycome: role of the Golgi apparatus
Glycans are one of the four biopolymers of the cell and they play important roles in cellular
and organismal physiology. They consist of both linear and branched structures and are …
and organismal physiology. They consist of both linear and branched structures and are …
Structural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayer
Nucleotide sugars are the activated form of monosaccharides used by glycosyltransferases
during glycosylation. In eukaryotes the SLC35 family of solute carriers are responsible for …
during glycosylation. In eukaryotes the SLC35 family of solute carriers are responsible for …
Assembly of B4GALT1/ST6GAL1 heteromers in the Golgi membranes involves lateral interactions via highly charged surface domains
β-1, 4-Galactosyltransferase 1 (B4GALT1) and ST6 β-galactoside α-2, 6-sialyltransferase 1
(ST6GAL1) catalyze the successive addition of terminal β-1, 4–linked galactose and α-2, 6 …
(ST6GAL1) catalyze the successive addition of terminal β-1, 4–linked galactose and α-2, 6 …