Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction

AS Monzel, JA Enríquez, M Picard - Nature metabolism, 2023 - nature.com
Mitochondria have cell-type specific phenotypes, perform dozens of interconnected
functions and undergo dynamic and often reversible physiological recalibrations. Given their …

Skeletal muscle alterations in patients with acute Covid‐19 and post‐acute sequelae of Covid‐19

MN Soares, M Eggelbusch, E Naddaf… - Journal of cachexia …, 2022 - Wiley Online Library
Skeletal muscle‐related symptoms are common in both acute coronavirus disease (Covid)‐
19 and post‐acute sequelae of Covid‐19 (PASC). In this narrative review, we discuss …

Possible pathogenesis and prevention of long COVID: SARS-CoV-2-induced mitochondrial disorder

TH Chen, CJ Chang, PH Hung - International journal of molecular …, 2023 - mdpi.com
Patients who have recovered from coronavirus disease 2019 (COVID-19) infection may
experience chronic fatigue when exercising, despite no obvious heart or lung abnormalities …

The role of oxidative stress in the pathogenesis of infections with coronaviruses

C Gain, S Song, T Angtuaco, S Satta… - Frontiers in …, 2023 - frontiersin.org
Coronaviruses can cause serious respiratory tract infections and may also impact other end
organs such as the central nervous system, the lung and the heart. The coronavirus disease …

Reactive oxygen species: angels and demons in the life of a neuron

K Biswas, K Alexander, MM Francis - NeuroSci, 2022 - mdpi.com
Reactive oxygen species (ROS) have emerged as regulators of key processes supporting
neuronal growth, function, and plasticity across lifespan. At normal physiological levels, ROS …

Pathophysiological involvement of host mitochondria in SARS-CoV-2 infection that causes COVID-19: A comprehensive evidential insight

C Bhowal, S Ghosh, D Ghatak, R De - Molecular and cellular biochemistry, 2023 - Springer
SARS-CoV-2 is a positive-strand RNA virus that infects humans through the nasopharyngeal
and oral route causing COVID-19. Scientists left no stone unturned to explore a targetable …

[HTML][HTML] Pathogenic mitochondrial dysfunction and metabolic abnormalities

WH Moos, DV Faller, IP Glavas, DN Harpp… - Biochemical …, 2021 - Elsevier
Herein we trace links between biochemical pathways, pathogenesis, and metabolic
diseases to set the stage for new therapeutic advances. Cellular and acellular …

Oxidative Biomarkers Associated with the Pulmonary Manifestation of Post-COVID-19 Complications

K Siekacz, A Kumor-Kisielewska… - Journal of Clinical …, 2023 - mdpi.com
Introduction: The role of mitochondria in post coronavirus disease 2019 (post-COVID-19)
complications is unclear, especially in the long-term pulmonary complications. This study …

Severe acute respiratory syndrome coronaviruses contributing to mitochondrial dysfunction: Implications for post-COVID complications

SP Kabekkodu, S Chakrabarty, P Jayaram, S Mallya… - Mitochondrion, 2023 - Elsevier
Mitochondria play a central role in oxidative phosphorylation (OXPHOS), bioenergetics
linked with ATP production, fatty acids biosynthesis, calcium signaling, cell cycle regulation …

Plasma miR-195-5p predicts the severity of Covid-19 in hospitalized patients

AI Moatar, AR Chis, M Romanescu, PD Ciordas… - Scientific Reports, 2023 - nature.com
Predicting the clinical course of Covid-19 is a challenging task, given the multi-systemic
character of the disease and the paucity of minimally invasive biomarkers of disease …