Dendritic cell subsets in cancer immunity and tumor antigen sensing

A Del Prete, V Salvi, A Soriani, M Laffranchi… - Cellular & molecular …, 2023 - nature.com
Dendritic cells (DCs) exhibit a specialized antigen-presenting function and play crucial roles
in both innate and adaptive immune responses. Due to their ability to cross-present tumor …

[HTML][HTML] Human gut-associated lymphoid tissues (GALT); diversity, structure, and function

UM Mörbe, PB Jørgensen, TM Fenton, N von Burg… - Mucosal …, 2021 - Elsevier
Gut-associated lymphoid tissues (GALT) are the key antigen sampling and adaptive immune
inductive sites within the intestinal wall. Human GALT includes the multi-follicular Peyer's …

Dendritic cell regulation of T helper cells

X Yin, S Chen, SC Eisenbarth - Annual review of immunology, 2021 - annualreviews.org
As the professional antigen-presenting cells of the immune system, dendritic cells (DCs)
sense the microenvironment and shape the ensuing adaptive immune response. DCs can …

Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responses

F Bayerl, P Meiser, S Donakonda, A Hirschberger… - Immunity, 2023 - cell.com
Type 1 conventional dendritic cells (cDC1s) are critical for anti-cancer immunity. Protective
anti-cancer immunity is thought to require cDC1s to sustain T cell responses within tumors …

Dendritic cell subsets in T cell programming: location dictates function

SC Eisenbarth - Nature Reviews Immunology, 2019 - nature.com
Dendritic cells (DCs) can be viewed as translators between innate and adaptive immunity.
They integrate signals derived from tissue infection or damage and present processed …

Human dendritic cell subsets: an update

M Collin, V Bigley - Immunology, 2018 - Wiley Online Library
Dendritic cells (DC) are a class of bone‐marrow‐derived cells arising from lympho‐myeloid
haematopoiesis that form an essential interface between the innate sensing of pathogens …

[HTML][HTML] NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control

JP Böttcher, E Bonavita, P Chakravarty, H Blees… - Cell, 2018 - cell.com
Conventional type 1 dendritic cells (cDC1) are critical for antitumor immunity, and their
abundance within tumors is associated with immune-mediated rejection and the success of …

Dendritic cells revisited

M Cabeza-Cabrerizo, A Cardoso… - Annual review of …, 2021 - annualreviews.org
Dendritic cells (DCs) possess the ability to integrate information about their environment and
communicate it to other leukocytes, shaping adaptive and innate immunity. Over the years, a …

C-type lectins in immunity and homeostasis

GD Brown, JA Willment, L Whitehead - Nature Reviews Immunology, 2018 - nature.com
The C-type lectins are a superfamily of proteins that recognize a broad repertoire of ligands
and that regulate a diverse range of physiological functions. Most research attention has …

Human dendritic cells: their heterogeneity and clinical application potential in cancer immunotherapy

TA Patente, MP Pinho, AA Oliveira… - Frontiers in …, 2019 - frontiersin.org
Dendritic cells (DC) are professional antigen presenting cells, uniquely able to induce naïve
T cell activation and effector differentiation. They are, likewise, involved in the induction and …