This review summarizes the advancements in rhodium-catalyzed asymmetric C–H
functionalization reactions during the last two decades. Parallel to the rapidly developed …

The development of new methods for the direct functionalization of unactivated C–H bonds
is ushering in a paradigm shift in the field of retrosynthetic analysis. In particular, the catalytic …

The transition-metal-catalyzed addition of C–H bonds to carbonyls, imines, and related
polarized π bonds has emerged as a particularly efficient and powerful approach for the …

Direct C–H functionalization has recently emerged as one of the most efficient strategies to
access structurally complex molecules from readily accessible feedstocks in an atom-and …

Transition-metal-catalyzed nucleophilic addition of organometallic reagents to polar
unsaturated substrates is one of the most important and powerful bond-forming strategies …

Esters are valuable commodity chemicals widely found in agrochemicals, pharmaceuticals,
and advanced materials. They are also important synthetic building blocks for chemical …

Cobalt–chiral diphoshine catalytic systems promote intramolecular hydroacylation reactions
of 2-acylbenzaldehydes and 2-alkenylbenzaldehydes to afford phthalide and indanone …

A new family of stereoconvergent cross-couplings of unactivated secondary alkyl
electrophiles has been developed, specifically, arylamine-directed alkyl–alkyl Suzuki …

We describe a cobalt-catalyzed hydroacylation of 1, 3-dienes with non-chelating aldehydes.
Aromatic aldehydes provide 1, 4-addition products as the major isomer, while aliphatic …

Conspectus By using transition metal catalysts, chemists have altered the “logic of chemical
synthesis” by enabling the functionalization of carbon–hydrogen bonds, which have …