Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

Calcific aortic valve disease (CAVD) is the end result of active cellular processes that lead to
the progressive fibrosis and calcification of aortic valve leaflets. In western populations …

Neurodegenerative disease are frequently characterized by microglia activation and/or
leukocyte infiltration in the parenchyma of the central nervous system and at the molecular …

Nicotine contained in cigarette smoke contributes to the onset of several diseases, including
osteoporosis, whose emerging pathogenic mechanism is associated with osteoblasts …

Most mammalian tissue cells experience oxygen partial pressures in vivo equivalent to 1–
6% O2 (ie, physioxia). In standard cell culture, however, headspace O2 levels are usually …

Bone is a tissue with constant remodeling, where osteoblasts form and osteoclasts degrade
bone. Both cell types are highly specialized in their function and both form from precursors …

Reactive oxygen species (ROS) can cause cellular damage and promote cancer
development. Besides such harmful consequences of overproduction of ROS, all cells utilize …

This study sought to investigate whether reactive oxygen species (ROS)–generating
reduced nicotinamide adenine dinucleotide phosphate oxidase 2 (Nox2) contributes to …

The main function of NADPH oxidases is to catalyse the formation of reactive oxygen
species (ROS). NADPH oxidase 4 (NOX4) is expressed at high levels in kidney tubular cells …

Reactive oxygen and nitrogen species (RONS such as H 2 O 2, nitric oxide) confer redox
regulation of essential cellular functions (eg differentiation, proliferation, migration …