The suite of currently used drugs can be divided into two categories–traditional 'small
molecule'drugs with typical molecular weights of< 500 Da but with oral bioavailability, and …

Peptides are molecules of paramount importance in the fields of health care and nutrition.
Several technologies for their production are now available, among which chemical and …

Cyclic pentapeptides are not known to exist in α-helical conformations. CD and NMR spectra
show that specific 20-membered cyclic pentapeptides, Ac−(cyclo-1, 5)[KxxxD]-NH2 and Ac …

Filoviridae currently includes five official and one proposed genera. Genus Ebolavirus
includes five established and one proposed ebolavirus species for Bombali virus (BOMV) …

The first ratiometric fluorescent reporter was designed for the detection of cardiac troponin I
(cTnI), a key protein elicited during cardiac muscle cell death. In designing this abiotic …

Protein–protein interactions are ubiquitous, essential to almost all known biological
processes, and offer attractive opportunities for therapeutic intervention. Developing small …

Due to the pivotal roles that protein-protein interactions play in a plethora of biological
processes, the design of therapeutic agents targeting these interactions has become an …

Cancer vaccines designed to elicit an antibody response that target antigenic sites on a
tumor antigen must closely mimic the three-dimensional structure of the corresponding …

Preventative medicine in the form of vaccination had a huge impact on human health in the
20th Century. Vaccines are now recognized as the most effective line of defence against …

Characterizing the antibody reactome for circulating antibodies provide insight into
pathogen exposure, allergies and autoimmune diseases. This is important for biomarker …