Intraflagellar transport: mechanisms of motor action, cooperation, and cargo delivery
Intraflagellar transport (IFT) is a form of motor‐dependent cargo transport that is essential for
the assembly, maintenance, and length control of cilia, which play critical roles in motility …
the assembly, maintenance, and length control of cilia, which play critical roles in motility …
Stochastic mechano-chemical kinetics of molecular motors: a multidisciplinary enterprise from a physicist's perspective
D Chowdhury - Physics Reports, 2013 - Elsevier
A molecular motor is made of either a single macromolecule or a macromolecular complex.
Just like their macroscopic counterparts, molecular motors “transduce” input energy into …
Just like their macroscopic counterparts, molecular motors “transduce” input energy into …
Tug-of-war in motor protein ensembles revealed with a programmable DNA origami scaffold
ND Derr, BS Goodman, R Jungmann, AE Leschziner… - Science, 2012 - science.org
Cytoplasmic dynein and kinesin-1 are microtubule-based motors with opposite polarity that
transport a wide variety of cargo in eukaryotic cells. Many cellular cargos demonstrate …
transport a wide variety of cargo in eukaryotic cells. Many cellular cargos demonstrate …
Measuring molecular motor forces in vivo: implications for tug-of-war models of bidirectional transport
C Leidel, RA Longoria, FM Gutierrez, GT Shubeita - Biophysical journal, 2012 - cell.com
Molecular motor proteins use the energy released from ATP hydrolysis to generate force and
haul cargoes along cytoskeletal filaments. Thus, measuring the force motors generate …
haul cargoes along cytoskeletal filaments. Thus, measuring the force motors generate …
Gliding motility of the diatom Craspedostauros australis coincides with the intracellular movement of raphid-specific myosins
Raphid diatoms are one of the few eukaryotes capable of gliding motility, which is
remarkably fast and allows for quasi-instantaneous directional reversals. Besides other …
remarkably fast and allows for quasi-instantaneous directional reversals. Besides other …
Force generated by two kinesin motors depends on the load direction and intermolecular coupling
Kinesins are molecular motors that carry cellular cargoes. While the mechanics of single
kinesins are well characterized experimentally, the behavior of multiple kinesins varies …
kinesins are well characterized experimentally, the behavior of multiple kinesins varies …
Collective dynamics of processive cytoskeletal motors
RT McLaughlin, MR Diehl, AB Kolomeisky - Soft matter, 2016 - pubs.rsc.org
Major cellular processes are supported by various biomolecular motors that usually operate
together as teams. We present an overview of the collective dynamics of processive …
together as teams. We present an overview of the collective dynamics of processive …
Self-organized optimal packing of kinesin-5-driven microtubule asters scales with cell size
N Khetan, G Pruliere, C Hebras… - Journal of cell …, 2021 - journals.biologists.com
Radial microtubule (MT) arrays or asters determine cell geometry in animal cells. Multiple
asters interacting with motors, such as those in syncytia, form intracellular patterns, but the …
asters interacting with motors, such as those in syncytia, form intracellular patterns, but the …
Morphological and dynamical properties of semiflexible filaments driven by molecular motors
We consider an explicit model of a semiflexible filament moving in two dimensions on a
gliding assay of motor proteins, which attach to and detach from filament segments …
gliding assay of motor proteins, which attach to and detach from filament segments …
Long‐Range Transport of Giant Vesicles along Microtubule Networks
We report on a minimal system to mimic intracellular transport of membrane‐bounded,
vesicular cargo. In a cell‐free assay, purified kinesin‐1 motor proteins were directly …
vesicular cargo. In a cell‐free assay, purified kinesin‐1 motor proteins were directly …