Kidney lipid dysmetabolism and lipid droplet accumulation in chronic kidney disease

A Mitrofanova, S Merscher, A Fornoni - Nature Reviews Nephrology, 2023 - nature.com
Chronic kidney disease (CKD) is a global health problem with rising incidence and
prevalence. Among several pathogenetic mechanisms responsible for disease progression …

Exogenous H2S promotes ubiquitin‐mediated degradation of SREBP1 to alleviate diabetic cardiomyopathy via SYVN1 S‐sulfhydration

S Zhang, M Wang, H Li, Q Li, N Liu… - Journal of cachexia …, 2023 - Wiley Online Library
Background Diabetic cardiomyopathy, a distinctive complication of diabetes mellitus, has
been correlated with the presence of intracellular lipid deposits. However, the intricate …

Porcine reproductive and respiratory syndrome virus upregulates SMPDL3B to promote viral replication by modulating lipid metabolism

HH Shen, Q Zhao, YP Wen, R Wu, SY Du, XB Huang… - Iscience, 2023 - cell.com
Porcine reproductive and respiratory syndrome virus (PRRSV) poses a severe threat to the
health of pigs globally. Host factors play a critical role in PRRSV replication. Using PRRSV …

A Robust Phenotypic Screening Assay Utilizing Human Podocytes to Identify Agents that Modulate Lipid Droplets

M Gurumani, SK Mallela, J Varona, S Merscher… - … : Methods and Protocols, 2023 - Springer
Lipid droplets (LDs), initially thought to be mere lipid storage structures, are highly dynamic
organelles with complex functions that control cell fate and behavior. In recent years, their …