Post‐translational modifications drive secondary metabolite biosynthesis in Aspergillus: a review

K Yang, J Tian, NP Keller - Environmental Microbiology, 2022 - Wiley Online Library
Post‐translational modifications (PTMs) are important for protein function and regulate
multiple cellular processes and secondary metabolites (SMs) in fungi. Aspergillus species …

Post-translational modifications drive success and failure of fungal–host interactions

C Retanal, B Ball, J Geddes-McAlister - Journal of Fungi, 2021 - mdpi.com
Post-translational modifications (PTMs) change the structure and function of proteins and
regulate a diverse array of biological processes. Fungal pathogens rely on PTMs to …

Lysine acetylation contributes to development, aflatoxin biosynthesis and pathogenicity in Aspergillus flavus

G Yang, Y Yue, S Ren, M Yang, Y Zhang… - Environmental …, 2019 - Wiley Online Library
Aspergillus flavus is a pathogenic fungus that produces carcinogenic aflatoxins, posing a
great threat to crops, animals and humans. Lysine acetylation is one of the most important …

On and Off: Epigenetic Regulation of C. albicans Morphological Switches

E Iracane, S Vega-Estévez, A Buscaino - Pathogens, 2021 - mdpi.com
The human fungal pathogen Candida albicans is a dimorphic opportunistic pathogen that
colonises most of the human population without creating any harm. However, this fungus …

The function and regulation of heat shock transcription factor in Cryptococcus

C Suo, Y Gao, C Ding, T Sun - Frontiers in Cellular and Infection …, 2023 - frontiersin.org
Cryptococcus species are opportunistic human fungal pathogens. Survival in a hostile
environment, such as the elevated body temperatures of transmitting animals and humans …

Identification and assessment of pulmonary Cryptococcus neoformans infection by blood serum surface-enhanced Raman spectroscopy

S Zhu, Y Li, H Gao, G Hou, X Cui, S Chen… - Spectrochimica Acta Part …, 2021 - Elsevier
Cryptococcus neoformans (C. neoformans) is a causative agent for acute pulmonary
infection, which can further develop to lethal meningoencephalitis if untreated. The …

Significant enhancement of edible Monascus azaphilone pigments production via targeted improvement of the expression of histone deacetylase MrHos2

Y Lu, B Liu, Z Mao, Y Huang, Q Yan, F Chen, Y Shao - Food Bioscience, 2024 - Elsevier
Monascus azaphilone pigments (MonAzPs) are beneficial secondary metabolites secreted
by Monascus spp., which have great potentials to be used in industrial fields besides food …

The fungal‐specific histone acetyltransferase Rtt109 regulates development, DNA damage response, and virulence in Aspergillus fumigatus

Y Zhang, J Fan, J Ye, L Lu - Molecular microbiology, 2021 - Wiley Online Library
In eukaryotes, histone acetylation catalyzed by histone acetyltransferase (HAT) has been
demonstrated to be critical for various physiological processes. However, the biological …

Protein acetylation/deacetylation: a potential strategy for fungal infection control

J Chen, Q Liu, L Zeng, X Huang - Frontiers in Microbiology, 2020 - frontiersin.org
Protein acetylation is a universal post-translational modification that fine-tunes the major
cellular processes of many life forms. Although the mechanisms regulating protein …

Chromatin profiling reveals heterogeneity in clinical isolates of the human pathogen Aspergillus fumigatus

AC Colabardini, F Wang, Z Miao, L Pardeshi… - PLoS …, 2022 - journals.plos.org
Invasive Pulmonary Aspergillosis, which is caused by the filamentous fungus Aspergillus
fumigatus, is a life-threatening infection for immunosuppressed patients. Chromatin structure …