USP7: Structure, substrate specificity, and inhibition
A Pozhidaeva, I Bezsonova - DNA repair, 2019 - Elsevier
Turnover of cellular proteins is regulated by Ubiquitin Proteasome System (UPS).
Components of this pathway, including the proteasome, ubiquitinating enzymes and …
Components of this pathway, including the proteasome, ubiquitinating enzymes and …
[HTML][HTML] Molecular mechanisms of DUBs regulation in signaling and disease
Y Li, D Reverter - International journal of molecular sciences, 2021 - mdpi.com
The large family of deubiquitinating enzymes (DUBs) are involved in the regulation of a
plethora of processes carried out inside the cell by protein ubiquitination. Ubiquitination is a …
plethora of processes carried out inside the cell by protein ubiquitination. Ubiquitination is a …
USP7 small-molecule inhibitors interfere with ubiquitin binding
L Kategaya, P Di Lello, L Rougé, R Pastor, KR Clark… - Nature, 2017 - nature.com
The ubiquitin system regulates essential cellular processes in eukaryotes. Ubiquitin is
ligated to substrate proteins as monomers or chains and the topology of ubiquitin …
ligated to substrate proteins as monomers or chains and the topology of ubiquitin …
[HTML][HTML] The HSV-1 ubiquitin ligase ICP0: Modifying the cellular proteome to promote infection
Abstract Herpes simplex virus 1 (HSV-1) hijacks ubiquitination machinery to modify the
cellular proteome to create an environment permissive for virus replication. HSV-1 encodes …
cellular proteome to create an environment permissive for virus replication. HSV-1 encodes …
[HTML][HTML] Regulation of USP7: a high incidence of E3 complexes
Ubiquitin (Ub) conjugation is a critical signalling process in eukaryotic cells. The precise
regulation of deubiquitination is an important component of this signalling cascade. Here …
regulation of deubiquitination is an important component of this signalling cascade. Here …
Current and future directions of USP7 interactome in cancer study
HB Park, KH Baek - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
The ubiquitin-proteasome system (UPS) is an essential protein quality controller for
regulating protein homeostasis and autophagy. Ubiquitination is a protein modification …
regulating protein homeostasis and autophagy. Ubiquitination is a protein modification …
[HTML][HTML] Identification and characterization of USP7 targets in cancer cells
A Georges, E Marcon, J Greenblatt, L Frappier - Scientific Reports, 2018 - nature.com
The ubiquitin specific protease, USP7, regulates multiple cellular pathways relevant for
cancer through its ability to bind and sometimes stabilize specific target proteins through …
cancer through its ability to bind and sometimes stabilize specific target proteins through …
[HTML][HTML] Ubiquitin specific peptidases and prostate cancer
Y Guo, S Cui, Y Chen, S Guo, D Chen - PeerJ, 2023 - peerj.com
Protein ubiquitination is an important post-translational modification mechanism, which
regulates protein stability and activity. The ubiquitination of proteins can be reversed by …
regulates protein stability and activity. The ubiquitination of proteins can be reversed by …
[HTML][HTML] Active site-targeted covalent irreversible inhibitors of USP7 impair the functions of Foxp3+ T-regulatory cells by promoting ubiquitination of Tip60
Accumulation of Foxp3+ T-regulatory (Treg) cells in the tumor microenvironment is
associated with tumor immune evasion and poor patient outcome in the case of many solid …
associated with tumor immune evasion and poor patient outcome in the case of many solid …
[HTML][HTML] Ubiquitin-specific peptidase 7: a novel deubiquitinase that regulates protein homeostasis and cancers
L Zhou, T Ouyang, M Li, T Hong, W Meng… - Frontiers in …, 2021 - frontiersin.org
Ubiquitin-Specific Peptidase 7 (USP7), or herpes virus-associated protease (HAUSP), is the
largest family of the deubiquitinating enzymes (DUBs). Recent studies have shown that …
largest family of the deubiquitinating enzymes (DUBs). Recent studies have shown that …