Metastatic melanoma is one of the most aggressive tumors, with frequent mutations affecting
components of the MAPK pathway, mainly protein kinase BRAF. Despite promising initial …

Recently, the zebrafish has been established as one of the most important model organisms
for medical research. Several studies have proved that there is a high level of similarity …

Multidrug resistance (MDR) is the main challenge faced by cancer chemotherapy. Drug-
conjugate offers a promising strategy for breast cancer therapy. In this regard, we developed …

Biobanking of surplus human healthy and disease-derived tissues is essential for
diagnostics and translational research. An enormous amount of formalin-fixed and paraffin …

Simple Summary Resistance to standard therapies represents a major challenge in
melanoma treatment. This is mainly related to the high heterogeneity of this malignancy due …

Despite the recent impressive clinical success of immunotherapy against melanoma,
development of primary and adaptive resistance against immune checkpoint inhibitors …

Tigilanol tiglate (TT, also known as EBC-46) is a novel, plant-derived diterpene ester
possessing anticancer and wound-healing properties. Here, we show that TT-evoked PKC …

Background Tumour repopulation initiated by residual tumour cells in response to cytotoxic
therapy has been described clinically and biologically, but the mechanisms are unclear …

BRAF mutations are present in 30–50% of cases of cutaneous melanoma, and treatment
with selective BRAF and MEK inhibitors has been introduced. However, the development of …

Recently, the zebrafish has been established as one of the most important model organisms
for medical research. Several studies have proved that there is a high level of similarity …