Potential of Essential Oil-Based Anticholinesterase Insecticides against Anopheles Vectors: A Review
The insect nervous system is critical for its functional integrity. The cholinergic system, of
which acetylcholinesterase (AChE) is a key enzyme, is essential to the Anopheles …
which acetylcholinesterase (AChE) is a key enzyme, is essential to the Anopheles …
Bisbenzylisoquinolines from Cissampelos pareira L. as antimalarial agents: Molecular docking, pharmacokinetics analysis, and molecular dynamic simulation studies
Malaria is a major global health issue due to the emergence of resistance to most of the
available antimalarial drugs. There is an urgent need to discover new antimalarials to tackle …
available antimalarial drugs. There is an urgent need to discover new antimalarials to tackle …
[HTML][HTML] Exploring marine-derived compounds: In silico discovery of selective ketohexokinase (KHK) inhibitors for metabolic disease therapy
MS Alturki - Marine Drugs, 2024 - mdpi.com
The increasing prevalence of metabolic diseases, including nonalcoholic fatty liver disease
(NAFLD), obesity, and type 2 diabetes, poses significant global health challenges …
(NAFLD), obesity, and type 2 diabetes, poses significant global health challenges …
Beyond trial and error: Leveraging advanced software for Therapeutic discovery
In drug discovery, efficiency and precision are crucial elements that play pivotal roles in
saving lives, time, and financial resources while pursuing groundbreaking advancements …
saving lives, time, and financial resources while pursuing groundbreaking advancements …
High-throughput virtual screening of phenylpyrimidine derivatives as selective JAK3 antagonists using computational methods
In this study, we used phenylpyrimidine derivatives with known biological activity against
JAK3, a critical tyrosine kinase enzyme involved in signaling pathways, to find similar …
JAK3, a critical tyrosine kinase enzyme involved in signaling pathways, to find similar …
A poly (caprolactone)-cellulose nanocomposite hydrogel for transdermal delivery of hydrocortisone in treating psoriasis vulgaris
Psoriasis vulgaris (PV) is a common chronic disease, affecting much of the population.
Hydrocortisone (HCT) is currently utilized as a PV treatment; however, it is associated with …
Hydrocortisone (HCT) is currently utilized as a PV treatment; however, it is associated with …
In vitro and in silico analysis of the Anopheles anticholinesterase activity of terpenoids
TA Rants'o, LL Koekemoer, RL van Zyl - Parasitology International, 2023 - Elsevier
Abstract Anopheles gambiae, An. coluzzii, An. arabiensis, and An. funestus are major
vectors in high malaria endemic African regions. Various terpenoid classes form the main …
vectors in high malaria endemic African regions. Various terpenoid classes form the main …
A Micro-In-Macro Gastroretentive System for the Delivery of Narrow-Absorption Window Drugs
A micro-in-macro gastroretentive and gastrofloatable drug delivery system (MGDDS), loaded
with the model-drug ciprofloxacin, was developed in this study to address the limitations …
with the model-drug ciprofloxacin, was developed in this study to address the limitations …
Identification of DprE1 inhibitors for tuberculosis through integrated in-silico approaches
Abstract Decaprenylphosphoryl-β-D-ribose-2′-epimerase (DprE1), a crucial enzyme in the
process of arabinogalactan and lipoarabinomannan biosynthesis, has become the target of …
process of arabinogalactan and lipoarabinomannan biosynthesis, has become the target of …
The in silico and in vitro analysis of donepezil derivatives for Anopheles acetylcholinesterase inhibition
TA Rants'o, DG van Greunen, CJ van der Westhuizen… - Plos one, 2022 - journals.plos.org
Current studies on Anopheles anticholinesterase insecticides are focusing on identifying
agents with high selectivity towards Anopheles over mammalian targets …
agents with high selectivity towards Anopheles over mammalian targets …