Fluorescence lifetime imaging microscopy: fundamentals and advances in instrumentation, analysis, and applications

R Datta, TM Heaster, JT Sharick… - … of biomedical optics, 2020 - spiedigitallibrary.org
Significance: Fluorescence lifetime imaging microscopy (FLIM) is a powerful technique to
distinguish the unique molecular environment of fluorophores. FLIM measures the time a …

A review of augmented reality in robotic-assisted surgery

L Qian, JY Wu, SP DiMaio, N Navab… - IEEE Transactions on …, 2019 - ieeexplore.ieee.org
Augmented reality (AR) and robotic-assisted surgery (RAS) are both rapidly evolving
technologies in recent years. RAS systems, such as the da Vinci Surgical System, aim to …

Metaverse wearables for immersive digital healthcare: a review

K Kim, H Yang, J Lee, WG Lee - Advanced Science, 2023 - Wiley Online Library
The recent exponential growth of metaverse technology has been instrumental in reshaping
a myriad of sectors, not least digital healthcare. This comprehensive review critically …

Intraoperative margin assessment in oral and oropharyngeal cancer using label-free fluorescence lifetime imaging and machine learning

M Marsden, BW Weyers, J Bec, T Sun… - IEEE Transactions …, 2020 - ieeexplore.ieee.org
Objective: To demonstrate the diagnostic ability of label-free, point-scanning, fiber-based
Fluorescence Lifetime Imaging (FLIm) as a means of intraoperative guidance during oral …

Optical spectroscopy for in vivo medical diagnosis—a review of the state of the art and future perspectives

JA Kim, DJ Wales, GZ Yang - Progress in Biomedical …, 2020 - iopscience.iop.org
When light is incident to a biological tissue surface, combinations of optical processes occur,
such as reflection, absorption, elastic and non-elastic scattering, and fluorescence. Analysis …

Intraoperative molecular imaging: 3rd biennial clinical trials update

P Bou-Samra, N Muhammad, A Chang… - … of biomedical optics, 2023 - spiedigitallibrary.org
Significance This third biennial intraoperative molecular imaging (IMI) conference shows
how optical contrast agents have been applied to develop clinically significant endpoints …

Real-time diagnosis and visualization of tumor margins in excised breast specimens using fluorescence lifetime imaging and machine learning

J Unger, C Hebisch, JE Phipps, JL Lagarto… - Biomedical optics …, 2020 - opg.optica.org
Tumor-free surgical margins are critical in breast-conserving surgery. In up to 38% of the
cases, however, patients undergo a second surgery since malignant cells are found at the …

Mesoscopic fluorescence lifetime imaging: Fundamental principles, clinical applications and future directions

A Alfonso‐Garcia, J Bec, B Weyers… - Journal of …, 2021 - Wiley Online Library
Fluorescence lifetime imaging (FLIm) is an optical spectroscopic imaging technique capable
of real‐time assessments of tissue properties in clinical settings. Label‐free FLIm is sensitive …

Deep learning in macroscopic diffuse optical imaging

JT Smith, M Ochoa, D Faulkner… - Journal of Biomedical …, 2022 - spiedigitallibrary.org
Significance: Biomedical optics system design, image formation, and image analysis have
primarily been guided by classical physical modeling and signal processing methodologies …

The future of robotic surgery in otolaryngology–head and neck surgery

A Tamaki, JW Rocco, E Ozer - Oral Oncology, 2020 - Elsevier
Robotic surgery for management of head and neck pathologies has only been in practice for
little more than a decade. Since then, there has been a rapid development in the field of …