Abstract Calcium ions (Ca2+) are some of the most versatile signalling molecules, and they
have many physiological functions, prominently including muscle contraction, neuronal …

Mitochondria sense and respond to many stressors and can support cell survival or death
through energy production and signalling pathways. Mitochondrial responses depend on …

Interorganellar contacts are increasingly recognized as central to the control of cellular
behavior. These contacts, which typically involve a small fraction of the endomembrane …

Recent advances have revealed common pathological changes in neurodegenerative
diseases, such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral …

Calcium (Ca 2+) is considered one of the most-important biological cations, because it is
implicated in cell physiopathology and cell fate through a finely tuned signaling system. In …

Cellular organelles are not static but show dynamism—a property that is likely relevant for
their function. In addition, they interact with other organelles in a highly dynamic manner. In …

Background: Control of ER-mitochondrial Ca 2+ fluxes is a critical checkpoint to determine
cell fate under stress. The 75-kDa glucose-regulated protein (GRP75) is a key tether protein …

The endoplasmic reticulum (ER) and mitochondria are interconnected intracellular
organelles with vital roles in the regulation of cell signaling and function. While the ER …

Mitochondria form close physical contacts with a specialized domain of the endoplasmic
reticulum (ER), known as the mitochondria-associated membrane (MAM). This association …

The maintenance of cellular homeostasis involves the participation of multiple organelles.
These organelles are associated in space and time, and either cooperate or antagonize …