Significant progress has been made in the past four decades toward understanding the
structures and synthesis of bioactive peptides produced by microorganisms through the …

Our understanding of fatty acid biosynthesis in Escherichia coli has increased greatly in
recent years. Since the discovery that the intermediates of fatty acid biosynthesis are bound …

In Saccharopolyspora erythraea, the genes that govern synthesis of the polyketide portion of
the macrolide antibiotic erythromycin are organized in six repeated units that encode fatty …

Over the last eight years or so, genetic techniques have spearheaded significant advances
in our understanding of the structure and mechanisms of polyketide synthases (PKSs). Much …

ERYTHROMYCIN A, a clinically important polyketide antibiotic, is produced by the Gram-
positive bacterium Saccharopolyspora erythraea.. In an arrangement that seems to be …

The antimycobacterial compound ethambutol [Emb; dextro-2, 2'-(ethylenediimino)-di-1-
butanol] is used to treat tuberculosis as well as disseminated infections caused by …

Strep. to. my'ces. Gr. adj. streptos pliant, bent; Gr. masc. n. mukês fungus; NL masc. n.
Streptomyces pliant or bent fungus. Actinobacteria/Actinobacteria/Streptomycetales …

There is an astonishing array of microbial alcohol oxidoreductases. They display a wide
variety of substrate specificities and they fulfill several vital but quite different physiological …

Polyketide synthases (PKSs) are multifunctional enzymes that catalyze the biosynthesis of a
huge variety of carbon chains differing in their length and patterns of functionality and …

Covering: the literature up to April 2005The focus of this review is to highlight the structure,
bioactivity and biosynthesis of naturally occurring aryl-C-glycosides. General synthetic …