Obesity is known to have important roles in driving prostate cancer aggressiveness and increased mortality. Multiple mechanisms have been postulated for these clinical …
MJ Zacherl, FJ Gildehaus, L Mittlmeier… - Journal of Nuclear …, 2021 - Soc Nuclear Med
Treatment of advanced metastatic castration-resistant prostate cancer after failure of approved therapy options remains challenging. Prostate-specific membrane antigen (PSMA) …
GT Lee, N Nagaya, J Desantis, K Madura… - Molecular cancer …, 2021 - AACR
Although second-line antiandrogen therapy (SAT) is the standard of care in men with castration-resistant prostate cancer (CRPC), resistance inevitably occurs. One major …
F Khreish, Z Ghazal, RJ Marlowe, F Rosar… - European Journal of …, 2022 - Springer
Purpose Preliminary data from retrospective analyses and recent data from large randomized controlled trials suggest safety and efficacy of radioligand therapy (RLT) …
Y Lim, S Arora, SL Schuster, L Corey… - Nature …, 2021 - nature.com
The functional consequences of genetic variants within 5'untranslated regions (UTRs) on a genome-wide scale are poorly understood in disease. Here we develop a high-throughput …
EA Messner, TM Steele, MM Tsamouri, N Hejazi… - Biomedicines, 2020 - mdpi.com
The androgen receptor (AR) plays a predominant role in prostate cancer (PCa) pathology. It consists of an N-terminal domain (NTD), a DNA-binding domain (DBD), a hinge region (HR) …
Introduction Metastatic castrate resistant prostate cancer (mCPRC) remains an aggressive form of prostate cancer that no longer responds to traditional hormonal treatment alone …
W Zhang, AM Lee, S Jena, Y Huang… - Proceedings of the …, 2023 - National Acad Sciences
Prostate cancer (PC) is the most frequently diagnosed malignancy and a leading cause of cancer deaths in US men. Many PC cases metastasize and develop resistance to systemic …
K Kofman, M Levin - Progress in biophysics and molecular biology, 2024 - Elsevier
Cancer is a pernicious and pressing medical problem; moreover, it is a failure of multicellular morphogenesis that sheds much light on evolutionary developmental biology …