Myeloperoxidase (MPO) is a member of the superfamily of heme peroxidases that is mainly
expressed in neutrophils and monocytes. MPO-derived reactive species play a key role in …

White blood cells (WBCs) are a major component of immunity in response to pathogen
invasion. Neutrophils are the most abundant WBCs in humans, playing a central role in …

Aging accounts for increased risk and dismal outcome of ischemic stroke. Here, we
investigated the impact of age-related changes in the immune system on stroke. Upon …

MATERIALS AND METHODS Surgical preparation. The experimental animals were handled
in compliance with the Guiding Principles in the Use and Care of Animals published by the …

One of the major therapeutic goals of modern cardiology is to design strategies aimed at
minimizing myocardial necrosis and optimizing cardiac repair following myocardial …

Inflammatory response and cytokine elaboration are particularly active after myocardial
infarction and contribute to cardiac remodeling and eventual host outcome. The triggers of …

Myocardial ischemia-reperfusion injury is an important cause of impaired heart function in
the early postoperative period subsequent to cardiac surgery. Reactive oxygen species …

Cardiac surgery with cardiopulmonary bypass (CPB) induces an acute phase reaction that
has been implicated in the pathogenesis of several postoperative complications. Recent …

NLRP3 inflammasome is necessary for initiating acute sterile inflammation. Recent studies
have demonstrated that NLRP3 inflammasome is up-regulated and mediates myocardial …

Peroxisome proliferator-activated receptor γ (PPARγ) is a widely expressed ligand-
modulated transcription factor that governs the expression of genes involved in …