Background Binge drinking, characterized by heavy episodic alcohol consumption, poses
significant health hazards and increases the likelihood of developing an alcohol use …

Protein/protein interactions (PPI) play crucial roles in neuronal functions. Yet, their potential
as drug targets for brain disorders remains underexplored. The fibroblast growth factor 14 …

Background Alcohol use disorder (AUD) is a complex condition, and it remains unclear
which specific neuronal substrates mediate alcohol‐seeking and‐taking behaviors. Engram …

Striatal cholinergic interneurons (CINs) are key to regulating behavioral flexibility, involving
both extinguishing learned actions and adopting new ones. However, the mechanisms …

Relapse is a major challenge in treating opioid addiction, including oxycodone. During
abstinence, oxycodone seeking progressively increases, a phenomenon termed incubation …

Background A top-down neuronal circuit from the orbitofrontal cortex (OFC) to the
dorsomedial striatum (DMS) appears to be critical for cognitive flexibility. However, how OFC …

Striatal acetylcholine (ACh) has been linked to behavioral flexibility. A key component of
flexibility is down-regulating responding as valued cues and actions become decoupled …

Lack of cognitive flexibility is a hallmark of substance use disorders and has been
associated with drug-induced synaptic plasticity in the dorsomedial striatum (DMS). Yet the …

Traumatic brain injury (TBI) is a global health challenge, responsible for 30% of injury-
related deaths and significantly contributing to disability. Annually, over 50 million TBIs occur …

Prosapip1 is a brain-specific protein localized to the postsynaptic density, where it promotes
dendritic spine maturation in primary hippocampal neurons. However, nothing is known …