Oxidative stress is a component of many diseases, including atherosclerosis, chronic
obstructive pulmonary disease, Alzheimer disease and cancer. Although numerous small …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

Degradation of extracellular matrix (ECM) underlies loss of cartilage tissue in osteoarthritis,
a common disease for which no effective disease-modifying therapy currently exists. Here …

Knee osteoarthritis (KOA) is one of the most common degenerative diseases, and its core
feature is the degeneration and damage of articular cartilage. The cartilage degeneration of …

Providing a comprehensive review of reactions of oxidation for different classes of organic
compounds and polymers, and biological processes mediated by free radicals, Oxidation …

Free radicals and other oxidants are critical determinants of the cellular signaling pathways
involved in the pathogenesis of several human diseases including inflammatory diseases …

Thymoquinone (TQ) is the major active compound derived from Nigella sativa. Our aim of
this work was to evaluate the antioxidant and antiarthritic activity of TQ in Wistar rat by …

Throughout the last 2 decades, experimental evidence from in vitro studies and preclinical
models of disease has demonstrated that reactive oxygen and nitrogen species, including …

Reactive oxygen species (ROS) are produced mainly during oxidative phosphorylation and
by activated phagocytic cells during oxidative burst. The excessive production of ROS can …

An imbalance in reducing and oxidizing (redox) systems favoring a more oxidative
environment is present in asthma and linked to the pathophysiology of the defining …