Several large-scale genomic studies have supported an association between cases of
autism spectrum disorder and mutations in the genes SH3 and multiple ankyrin repeat …

Shank family proteins (Shank1, Shank2, and Shank3) are synaptic scaffolding proteins that
organize an extensive protein complex at the postsynaptic density (PSD) of excitatory …

Background Autism spectrum disorder (ASD) is a neurodevelopmental condition, which is
characterized by clinical heterogeneity and high heritability. Core symptoms of ASD include …

Autism spectrum disorders (ASDs) include three main conditions: autistic disorder (AD),
pervasive developmental disorder, not otherwise specified (PDD-NOS), and Asperger …

Autism spectrum disorder (ASD) is a complex heterogeneous consortium of pervasive
development disorders (PDD) which ranges from atypical autism, autism, and Asperger …

Shank/ProSAP proteins are essential to synaptic formation, development, and function.
Mutations in the family of SHANK genes are strongly associated with autism spectrum …

Intact synaptic homeostasis is a fundamental prerequisite for a healthy brain. Thus, it is not
surprising that altered synaptic morphology and function are involved in the molecular …

There is now compelling evidence that gene by environment interactions are important in
the etiology of autism spectrum disorders (ASDs). However, the mechanisms by which …

Shank3/PROSAP2 gene mutations are associated with cognitive impairment ranging from
mental retardation to autism. Shank3 is a large scaffold postsynaptic density protein …

Background Considerable clinical heterogeneity has been well documented amongst
individuals with autism spectrum disorders (ASD). However, little is known about the …