Interstitial fibrosis has a major role in the progression of renal diseases. Several animal
models are available for the study of renal fibrosis. The models of aminonucleoside-induced …

Congenital obstructive nephropathy accounts for the greatest fraction of chronic kidney
disease in children. Genetic and nongenetic factors responsible for the lesions are largely …

Activation of α-smooth muscle actin–positive myofibroblast cells is a key event in the
progression of chronic renal diseases that leads to end-stage renal failure. Although the …

Unilateral ureteral obstruction (UUO) is a model of renal injury characterized by progressive
tubulointerstitial fibrosis and renal damage, while relatively sparing the glomerulus and not …

Congenital obstructive nephropathy is the primary cause of chronic renal failure in children.
Rapid diagnosis and initiation of the treatment are vital to preserve function and/or to slow …

The end point of immune and nonimmune renal injury typically involves glomerular and
tubulointerstitial fibrosis. Although numerous studies have focused on the events that lead to …

Mammalian peroxidases are heme-containing enzymes that serve diverse biological roles,
such as host defense and hormone biosynthesis. A mammalian homolog of Drosophila …

Traditional Chinese medicine (TCM) has unique therapeutic effects for complex chronic
diseases. However, for the lack of an effective systematic approach, the research progress …

Ureteropelvic junction (UPJ) obstruction is the most frequently observed cause of obstructive
nephropathy in children. Neonatal and foetal animal models have been developed that …

Recovery following relief of unilateral ureteral obstruction in the neonatal rat. Background
Obstructive nephropathy is a primary cause of renal insufficiency in infants and children …