Cysteine cathepsins as therapeutic targets in immune regulation and immune disorders
Cysteine cathepsins, as the most abundant proteases found in the lysosomes, play a vital
role in several processes—such as protein degradation, changes in cell signaling, cell …
role in several processes—such as protein degradation, changes in cell signaling, cell …
Cathepsin V regulates cell cycle progression and histone stability in the nucleus of breast cancer cells
N Sereesongsaeng, JF Burrows, CJ Scott… - Frontiers in …, 2023 - frontiersin.org
Introduction: We previously identified that Cathepsin V (CTSV) expression is associated with
poor prognosis in ER+ breast cancer, particularly within the Luminal A subtype. Examination …
poor prognosis in ER+ breast cancer, particularly within the Luminal A subtype. Examination …
Cathepsin inhibitors nitroxoline and its derivatives inhibit SARS-CoV-2 infection
RM Bonotto, A Mitrović, I Sosič, P Martínez-Orellana… - Antiviral Research, 2023 - Elsevier
The severity of the SARS-CoV-2 pandemic and the recurring (re) emergence of viruses
prompted the development of new therapeutic approaches that target viral and host factors …
prompted the development of new therapeutic approaches that target viral and host factors …
Revisiting Concurrent Radiation Therapy, Temozolomide, and the Histone Deacetylase Inhibitor Valproic Acid for Patients with Glioblastoma—Proteomic Alteration …
Background: Glioblastoma (GBM) is the most common brain tumor with an overall survival
(OS) of less than 30% at two years. Valproic acid (VPA) demonstrated survival benefits …
(OS) of less than 30% at two years. Valproic acid (VPA) demonstrated survival benefits …
Different glycosylation profiles of cystatin F alter the cytotoxic potential of natural killer cells
Cystatin F, a cysteine peptidase inhibitor, is a potent modulator of NK cytotoxicity. By
inhibiting granule-mediated cytotoxicity pathway, cystatin F induces formation of non …
inhibiting granule-mediated cytotoxicity pathway, cystatin F induces formation of non …
Cysteine Cathepsins and Their Diagnostic Role in Breast Cancer
M Hosney, II Sarhan - Egyptian Academic Journal of …, 2024 - eajbsc.journals.ekb.eg
Background: A large class of proteolytic enzymes known as cysteine cathepsins are created
as pro-enzymes and are activated in slightly acidic conditions. They are crucial for both …
as pro-enzymes and are activated in slightly acidic conditions. They are crucial for both …