The endothelial cell layer plays a major role in the development and progression of
atherosclerosis. Endothelial NO synthase (eNOS) produces nitric oxide (NO) from L …

Vascular remodeling, ie whole-vessel structural reshaping, determines lumen caliber in
(patho) physiology. Here we review mechanisms underlying vessel remodeling, with …

Dihydroethidium (DHE) is a widely used sensitive superoxide (O2•−) probe. However, DHE
oxidation yields at least two fluorescent products, 2-hydroxyethidium (EOH), known to be …

Antioxidant enzymes have shown promise as a therapy for pathological conditions involving
increased production of reactive oxygen species (ROS). However the efficiency of their use …

Mitochondria and NADPH oxidase activation are concomitantly involved in pathogenesis of
many vascular diseases. However, possible cross-talk between those ROS-generating …

A new proteomics technique for analyzing 3-nitrotyrosine-containing peptides is presented
here. This technique is based on the combined fractional diagonal chromatography peptide …

By 2003, an estimated 34 million Americans had used cocaine according to the National
Survey on Drug Use & Health. About 5.9 million of those had used in the past 12 months …

Atherosclerosis remains the number one cause of death and disability worldwide.
Atherosclerosis is treated by revascularization procedures to restore blood flow to distal …

Peroxiredoxins (Prx) are efficient thiol-dependent peroxidases and key players in the
mechanism of H 2 O 2-induced redox signaling. Any structural change that could affect their …

Background Although hypercholesterolemia is a well-established risk factor for coronary
heart disease, evidence suggests that increased triglyceride (TG) concentrations are also an …