The pharmaceutical industry is now paying increased attention to continuous manufacturing.
While the revolution to continuous and automated manufacturing is deepening in most of the …

The Purdue Make It system is a unique automated platform capable of small-scale in situ
synthesis, screening small-molecule reactions, and performing direct label-free bioassays …

Spontaneous oxidation of compounds containing diverse X= Y moieties (eg, sulfonamides,
ketones, esters, sulfones) occurs readily in organic-solvent microdroplets. This surprising …

Tissue microarrays (TMAs) are commonly used for the rapid analysis of large numbers of
tissue samples, often in morphological assessments but increasingly in spectroscopic …

Alkynylation reactions are one of the most sought‐after synthetic methodologies due to the
versatility of C− C triple bond diversifications. Sonogashira coupling was widely used for the …

Exploration of synthetic transformations using high throughput experimentation (HTE) can
accelerate the rapid discovery of optimal conditions for organic reactions and improve our …

High-throughput experimentation for chemistry and chemical biology has emerged as a
highly impactful technology, particularly when applied to Direct-to-Biology. Analysis of the …

Late‐stage diversification of drug molecules is an important strategy in drug discovery that
can be facilitated by reaction screening using high‐throughput experimentation. Here we …

Metal nanoparticles have always attracted attention for applied catalysis in technical fields
including sensor applications. Biogenically synthesized nanoparticles are uniquely non …

This review was devoted to outlining the use and potential increasing application of the
Design of Experiment (DoE) approach to the rational and planned synthesis of inorganic …