Chronic lymphocytic leukemia (CLL) is characterized by the existence of subsets of patients
with (quasi) identical, stereotyped B-cell receptor (BcR) immunoglobulins. Patients in certain …

Chronic lymphocytic leukemia is a complex and heterogeneous hematological malignancy.
The advance of high-throughput multi-omics technologies has significantly influenced …

The clonotypic B cell receptor immunoglobulin (BcR IG) plays a seminal role in B cell
lymphoma development and evolution. From a clinical perspective, this view is supported by …

Abstract The t (14; 19)(q32; q13) often juxtaposes BCL3 with immunoglobulin heavy chain
(IGH) resulting in overexpression of the gene. In contrast to other oncogenic translocations …

Subset# 201 is a clinically indolent subgroup of patients with chronic lymphocytic leukemia
defined by the expression of stereotyped, mutated IGHV4-34/IGLV1-44 BCR Ig. Subset# 201 …

The p53 family member p63 exists as two major protein variants (TAp63 and ΔNp63) with
distinct expression patterns and functional properties. Whilst downstream target genes of …

The chromatin activation landscape of chronic lymphocytic leukemia (CLL) with stereotyped
B-cell receptor immunoglobulin is currently unknown. In this study, we report the results of a …

The ontogeny and evolution of chronic lymphocytic leukemia (CLL) are critically dependent
on interactions between leukemic cells and their microenvironment, including antigens, the …

The TP63 gene encodes two major protein variants; TAp63 contains a p53-like transcription
domain and consequently has tumor suppressor activities whereas ΔNp63 lacks this domain …

Long non-coding RNA has emerged as a key regulator of myriad gene functions. One such
lncRNA mrhl, reported by our group, was found to have important role in spermatogenesis …