Role of mitochondria in physiology of chondrocytes and diseases of osteoarthritis and rheumatoid arthritis
S Kan, M Duan, Y Liu, C Wang, J Xie - Cartilage, 2021 - journals.sagepub.com
Purpose of Review Mitochondria are recognized to be one of the most important organelles
in chondrocytes for their role in triphosphate (ATP) generation through aerobic …
in chondrocytes for their role in triphosphate (ATP) generation through aerobic …
Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair
Abstract mRNAs can be targeted to specific neuronal subcellular domains, which enables
rapid changes in the local proteome through local translation. This mRNA-based …
rapid changes in the local proteome through local translation. This mRNA-based …
Axonal transport and mitochondrial function in neurons
A Mandal, CM Drerup - Frontiers in Cellular Neuroscience, 2019 - frontiersin.org
The complex and elaborate architecture of a neuron poses a great challenge to the cellular
machinery which localizes proteins and organelles, such as mitochondria, to necessary …
machinery which localizes proteins and organelles, such as mitochondria, to necessary …
A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration
M Di Stefano, I Nascimento-Ferreira… - Cell Death & …, 2015 - nature.com
NAD metabolism regulates diverse biological processes, including ageing, circadian rhythm
and axon survival. Axons depend on the activity of the central enzyme in NAD biosynthesis …
and axon survival. Axons depend on the activity of the central enzyme in NAD biosynthesis …
The role of mitochondria in axon development and regeneration
GM Smith, G Gallo - Developmental neurobiology, 2018 - Wiley Online Library
Mitochondria are dynamic organelles that undergo transport, fission, and fusion. The three
main functions of mitochondria are to generate ATP, buffer cytosolic calcium, and generate …
main functions of mitochondria are to generate ATP, buffer cytosolic calcium, and generate …
Genetic convergence brings clarity to the enigmatic red line in ALS
C Cook, L Petrucelli - Neuron, 2019 - cell.com
Amyotrophic lateral sclerosis (ALS) is an aggressive neurodegenerative disorder that
orchestrates an attack on the motor nervous system that is unrelenting. Recent discoveries …
orchestrates an attack on the motor nervous system that is unrelenting. Recent discoveries …
Molecular control of local translation in axon development and maintenance
Highlights•Many mRNAs are translated in developing and mature CNS axons in
vivo.•Axonal translation is critical for synaptogenesis, remodelling and survival.•RNA …
vivo.•Axonal translation is critical for synaptogenesis, remodelling and survival.•RNA …
Metabolic regulation of mitochondrial protein biogenesis from a neuronal perspective
JT Hees, AB Harbauer - Biomolecules, 2022 - mdpi.com
Neurons critically depend on mitochondria for ATP production and Ca2+ buffering. They are
highly compartmentalized cells and therefore a finely tuned mitochondrial network …
highly compartmentalized cells and therefore a finely tuned mitochondrial network …
Subcellular transcriptomics—dissection of the mRNA composition in the axonal compartment of sensory neurons
ABSTRACT RNA localization is a regulatory mechanism that is conserved from bacteria to
mammals. Yet, little is known about the mechanism and the logic that govern the distribution …
mammals. Yet, little is known about the mechanism and the logic that govern the distribution …
Activation of the innate signaling molecule MAVS by bunyavirus infection upregulates the adaptor protein SARM1, leading to neuronal death
P Mukherjee, TA Woods, RA Moore, KE Peterson - Immunity, 2013 - cell.com
La Crosse virus (LACV), a zoonotic Bunyavirus, is a major cause of pediatric viral
encephalitis in the United States. A hallmark of neurological diseases caused by LACV and …
encephalitis in the United States. A hallmark of neurological diseases caused by LACV and …