Cyclomodulins are bacterial toxins that interfere with the eukaryotic cell cycle. A new
cyclomodulin called colibactin, which is synthetized by the pks genomic island, was …

Klebsiella pneumoniae is a notorious bacterium in clinical practice. Virulence, carbapenem‐
resistance and their convergence among K. pneumoniae are extensively discussed in this …

Colibactin is a chemically unstable small-molecule genotoxin that is produced by several
different bacteria, including members of the human gut microbiome,. Although the biological …

Members of complex microbial communities that reside in environments such as the
mammalian gut have evolved mechanisms of interspecies competition, which may be …

Background The plasmid-mediated resistance gene mcr-1 confers colistin resistance in
Escherichia coli and paves the way for the evolution to pan-drug resistance. We investigated …

Bacterial genotoxins (BTGX) induce DNA damage, which results in senescence or apoptosis
of the target cells if not properly repaired. Three BTGXs have been identified: the cytolethal …

Wound infections are often polymicrobial in nature, biofilm associated and therefore tolerant
to antibiotic therapy, and associated with delayed healing. Escherichia coli and …

Covering: up to 2021 Colibactin (s), a group of secondary metabolites produced by the pks
island (clb cluster) of Escherichia coli, shows genotoxicity relevant to colorectal cancer and …

The structure and mode of action of colibactin with its potential involvement in cancer have
been extensively studied but little is known about the intrinsic function of the biosynthetic …

The genotoxin colibactin produced by resident bacteria of the gut microbiota may have
tumorigenic effect by inducing DNA double-strand breaks in host cells. Yet, the effect of …