Role of sleep deprivation in immune-related disease risk and outcomes

S Garbarino, P Lanteri, NL Bragazzi… - Communications …, 2021 - nature.com
Modern societies are experiencing an increasing trend of reduced sleep duration, with
nocturnal sleeping time below the recommended ranges for health. Epidemiological and …

Circadian clock proteins and immunity

AM Curtis, MM Bellet, P Sassone-Corsi, LAJ O'Neill - Immunity, 2014 - cell.com
Immune parameters change with time of day and disruption of circadian rhythms has been
linked to inflammatory pathologies. A circadian-clock-controlled immune system might allow …

A circadian clock in macrophages controls inflammatory immune responses

M Keller, J Mazuch, U Abraham… - Proceedings of the …, 2009 - National Acad Sciences
Time of day-dependent variations of immune system parameters are ubiquitous phenomena
in immunology. The circadian clock has been attributed with coordinating these variations …

Dysregulation of inflammatory responses by chronic circadian disruption

O Castanon-Cervantes, M Wu, JC Ehlen… - The Journal of …, 2010 - journals.aai.org
Circadian rhythms modulate nearly every mammalian physiological process. Chronic
disruption of circadian timing in shift work or during chronic jet lag in animal models leads to …

[HTML][HTML] Molecular interactions between components of the circadian clock and the immune system

S Hergenhan, S Holtkamp, C Scheiermann - Journal of molecular biology, 2020 - Elsevier
The immune system is under control of the circadian clock. Many of the circadian rhythms
observed in the immune system originate in direct interactions between components of the …

Crosstalk between the circadian clock circuitry and the immune system

N Cermakian, T Lange, D Golombek… - Chronobiology …, 2013 - Taylor & Francis
Various features, components, and functions of the immune system present daily variations.
Immunocompetent cell counts and cytokine levels present variations according to the time of …

Neurobiological and behavioral mechanisms of circadian rhythm disruption in bipolar disorder: a critical multi‐disciplinary literature review and agenda for future …

MJ McCarthy, JF Gottlieb, R Gonzalez… - Bipolar …, 2022 - Wiley Online Library
Aim Symptoms of bipolar disorder (BD) include changes in mood, activity, energy, sleep,
and appetite. Since many of these processes are regulated by circadian function, circadian …

Bmal1 integrates mitochondrial metabolism and macrophage activation

RK Alexander, YH Liou, NH Knudsen, KA Starost, C Xu… - Elife, 2020 - elifesciences.org
Metabolic pathways and inflammatory processes are under circadian regulation. Rhythmic
immune cell recruitment is known to impact infection outcomes, but whether the circadian …

The circadian system: a regulatory feedback network of periphery and brain

FN Buijs, L León-Mercado, M Guzmán-Ruiz… - …, 2016 - journals.physiology.org
Circadian rhythms are generated by the autonomous circadian clock, the suprachiasmatic
nucleus (SCN), and clock genes that are present in all tissues. The SCN times these …

Circadian clocks, stress, and immunity

R Dumbell, O Matveeva, H Oster - Frontiers in endocrinology, 2016 - frontiersin.org
In mammals, molecular circadian clocks are present in most cells of the body, and this
circadian network plays an important role in synchronizing physiological processes and …