A decreased level of brain 5-hydroxytryptamine (5-HT) has been theorized to be a core
pathogenic factor in depression for half a century. The theory arose from clinical …

Abstract Serotonin (5-HT) has long been considered as a key transmitter in the
neurocircuitry controlling aggression. Impaired regulation of each subtype of 5-HT receptor …

Dysregulation of brain serotonin (5-HT) neurotransmission is thought to underlie mental
conditions as diverse as depression, anxiety disorders, bipolar disorder, autism, and …

Background Serotonin is a neurotransmitter that has been linked to a wide variety of
behaviors including feeding and body-weight regulation, social hierarchies, aggression and …

Background Functional movement disorders (FMDs), part of the wide spectrum of functional
neurological disorders (conversion disorders), are common and often associated with a poor …

Since its theoretical inception, psychopathy has been considered by philosophers,
clinicians, theorists, and empirical researchers to be substantially and critically explained by …

Abstract Tryptophan hydroxylase 2 (TPH2) is the rate-limiting enzyme in brain serotonin
synthesis. The TPH2 gene has frequently been investigated in relation to psychiatric …

Abstract Tryptophan hydroxylase-2 (TPH2) is a recently identified TPH isoform responsible
for neuronal serotonin (5-HT) synthesis, and TPH2 polymorphisms are associated with a …

Neuronal circuits in the brain that utilize the neurotransmitter serotonin are essential to the
regulation of mood and emotional expression. Disruptions in serotonin signaling underlie …

Abstract Serotonin (5‐HT) modulates the stress response by interacting with the hormonal
hypothalamic–pituitary–adrenal (HPA) axis and neuronal sympathetic nervous system …