Microglia are the resident innate immune cells in the brain with a major role in orchestrating
immune responses. They also provide a frontline of host defense in the central nervous …

Aging is the most prominent risk factor for late-onset Alzheimer's disease. Aging associates
with a chronic inflammatory state both in the periphery and in the central nervous system, the …

With the increase of population aging, the number of Alzheimer's disease (AD) patients is
also increasing. According to current estimates, approximately 11% of people over 65 suffer …

Proteins of the actin depolymerizing factor (ADF)/cofilin family are ubiquitous among
eukaryotes and are essential regulators of actin dynamics and function. Mammalian neurons …

Microglia, brain resident immune cells, modulate development, activity, and plasticity of the
central nervous system. Mechanistically implicated in numerous neurological pathologies …

Microglia maintain brain homeostasis through their ability to survey and phagocytose
danger‐associated molecular patterns (DAMPs). In Alzheimer's disease (AD), microglial …

Peripheral inflammation could constitute a risk factor for AD. This review summarizes the
research related to peripheral inflammation that appears to have a relationship with …

The ability of endocannabinoid (eCB) to change functional microglial phenotype can be
explored as a possible target for therapeutic intervention. Since the inhibition of fatty acid …

Interleukin 33 (IL-33) belongs to the IL-1 family and is localized in the nucleus. IL-33 is
primarily composed of three distinct domains, namely the N-terminal domain responsible for …

Depression is a prevalent psychiatric disorder. Microglial state transition has been found in
many neurological disorders including depression. Gypenosides (Gypenosides I-LXXVIII …