The complexity of nanoscale interactions between biomaterials and cells has limited the
realization of the ultimate vision of nanotechnology in diagnostics and therapeutics. As such …

With the recent FDA approval of the first siRNA‐derived therapeutic, RNA interference
(RNAi)‐mediated gene therapy is undergoing a transition from research to the clinical …

A major obstacle facing brain diseases such as Alzheimer's disease, multiple sclerosis,
brain tumors, and strokes is the blood–brain barrier (BBB). The BBB prevents the passage of …

Atherosclerotic plaques exhibit high deposition of cholesterol and macrophages. These are
not only the main components of the plaques but also key inflammation-triggering sources …

Cyclodextrin (CD), a cyclic oligosaccharide, is a pharmaceutical additive that improves the
solubility of hydrophobic compounds. Recent research has focused on the potential active …

Lysosomes play a central role in cellular homeostasis and alterations in this compartment
associate with many diseases. The most studied example is that of lysosomal storage …

Graphene oxide (GO), as a two-dimensional carbon nanosheet, has been extensively
studied for potential biomedical applications due to its notable properties. Although a …

Inhalation therapy of lipid-based carriers has great potential in direct target towards the root
of respiratory diseases, which make them superior over other drug deliveries. With the …

Background Atherosclerosis-related cardiovascular diseases (CVDs) are the leading cause
of mortality worldwide. Cholesterol crystals (CCs) induce inflammation in atherosclerosis …

Abstract Niemann-Pick type C (NP-C) disease is a rare and fatal neurodegenerative disease
typified by aberrations in intracellular lipid transport. Cholesterol and other lipids accumulate …