The epigenetic modifications of histones are versatile marks that are intimately connected to
development and disease pathogenesis including human cancers. In this review, we will …

Exploration of protein function and interaction is critical for discovering links among
genomics, proteomics, and disease state; yet, the immense complexity of proteomics found …

Bioorthogonal reactions, including the strain-promoted azide–alkyne cycloaddition (SPAAC)
and inverse electron demand Diels–Alder (iEDDA) reactions, have become increasingly …

The introduction of cell-based therapies has provided new and unique strategies to treat
many diseases and disorders including the recent approval of CAR-T cell therapy for the …

Only a small percentage of protein kinases have been shown to adopt a distinct inactive ATP-
binding site conformation, called the Asp-Phe-Gly-out (DFG-out) conformation. Given the …

Chromatin regulation is a critical aspect of nuclear function. Recent advances have provided
detailed information about dynamic three-dimensional organization of chromatin and its …

Glycans mediate many critical, long‐term biological processes, such as stem cell
differentiation. However, few methods are available for the sustained remodeling of cells …

Ubiquitin and ubiquitin-like (UBL) proteins regulate a vast variety of cellular functions. Some
UBL proteins are present in all cell types, while others are expressed only in certain cells or …

Multidomain protein kinases, central controllers of signal transduction, use regulatory
domains to modulate catalytic activity in a complex cellular environment. Additionally, these …

Photoinduced cross-linking (PIC) has become a powerful tool in chemical biology for the
identification and mapping of stable or transient interactions between biomacromolecules …