Drug delivery into the brain is regulated by the blood–brain interfaces. The blood–brain
barrier (BBB), the blood–cerebrospinal fluid barrier (BCSFB), and the blood–arachnoid …

Transporter systems involved in the permeation of drugs and solutes across biological
membranes are recognized as key determinants of pharmacokinetics. Typically, the action of …

Efflux proteins at the blood–brain barrier provide a mechanism for export of waste products
of normal metabolism from the brain and help to maintain brain homeostasis. They also …

In humans, approximately 70% of drugs are eliminated through the liver. This process is
governed by the concerted action of membrane transporters and metabolic enzymes …

Background Cancer patients undergoing Doxorubicin (DOX) treatment are susceptible to
acute and chronic cardiac anomalies, including aberrant arrhythmias, ventricular …

Chemotherapy is an important method for the treatment of lung cancer, but multidrug
resistance (MDR) greatly reduces the efficacy. The superfamily of ATP-binding cassette …

As the field of PET has expanded and an ever-increasing number and variety of compounds
have been radiolabeled as potential in vivo tracers of biochemistry, transporters have …

Abstract Purpose of Review Currently, cardiotoxicity is monitored through echocardiography
or multigated acquisition scanning and is defined as 10% or higher LVEF reduction. The …

Commercial 68Ge/68Ga generators provide a means to produce positron emission
tomography agents on site without use of a cyclotron. This development has led to a rapid …

Thioflavin T (ThT), a positively charged heterocyclic small molecule, is a widely used
fluorescent marker of amyloid pathophysiology to confirm the cause of death in post mortem …