Abstract The Janus kinases (JAKs) and signal transducer and activator of transcription
(STAT) proteins, particularly STAT3, are among the most promising new targets for cancer …

Recent years have seen significant efforts in understanding and modulating the immune
response in cancer. In this context, immunosuppressive cells, including regulatory T cells …

Although obesity is known to be critical for cancer development, how obesity negatively
impacts antitumor immune responses remains largely unknown. Here, we show that …

Signal transducer and activator of transcription 3 (STAT3), a member of the STAT family,
discovered in the cytoplasm of almost all types of mammalian cells, plays a significant role in …

Immunocheckpoint proteins of tumor infiltrating lymphocytes play an important role in tumor
prognosis in the course of tumor clinicopathology. PD‐1 (Programmed cell death protein 1) …

Cancer arises in the context of an in vivo tumor microenvironment. This microenvironment is
both a cause and consequence of tumorigenesis. Tumor and host cells co-evolve …

Signal transducer and activator of transcription 3 (STAT3) is one of the crucial transcription
factors, responsible for regulating cellular proliferation, cellular differentiation, migration …

Treg play a central role in maintenance of self tolerance and homeostasis through
suppression of self-reactive T cell populations. In addition to that role, Treg also survey …

Regulatory T cells (Treg) are well-known for their immune regulatory potential and are
essential for maintaining immune homeostasis. The rationale of Treg-based immunotherapy …

Sphingosine‐1‐phosphate (S1P) is a bioactive sphingolipid metabolite involved in many
critical cell processes. It is produced by the phosphorylation of sphingosine by sphingosine …