The structure of the nuclear pore complex (an update)
The nuclear pore complex (NPC) serves as the sole bidirectional gateway of
macromolecules in and out of the nucleus. Owing to its size and complexity (∼ 1,000 protein …
macromolecules in and out of the nucleus. Owing to its size and complexity (∼ 1,000 protein …
The nuclear pore complex: understanding its function through structural insight
Nuclear pore complexes (NPCs) fuse the inner and outer nuclear membranes to form
channels across the nuclear envelope. They are large macromolecular assemblies with a …
channels across the nuclear envelope. They are large macromolecular assemblies with a …
[HTML][HTML] Comprehensive structure and functional adaptations of the yeast nuclear pore complex
CW Akey, D Singh, C Ouch, I Echeverria, I Nudelman… - Cell, 2022 - cell.com
Nuclear pore complexes (NPCs) mediate the nucleocytoplasmic transport of
macromolecules. Here we provide a structure of the isolated yeast NPC in which the inner …
macromolecules. Here we provide a structure of the isolated yeast NPC in which the inner …
Identification of potent inhibitors of NEK7 protein using a comprehensive computational approach
NIMA related Kinases (NEK7) plays an important role in spindle assembly and mitotic
division of the cell. Over expression of NEK7 leads to the progression of different cancers …
division of the cell. Over expression of NEK7 leads to the progression of different cancers …
Phase separation mediates NUP98 fusion oncoprotein leukemic transformation
NUP98 fusion oncoproteins (FO) are drivers in pediatric leukemias and many transform
hematopoietic cells. Most NUP98 FOs harbor an intrinsically disordered region from NUP98 …
hematopoietic cells. Most NUP98 FOs harbor an intrinsically disordered region from NUP98 …
Architecture of the linker-scaffold in the nuclear pore
INTRODUCTION In eukaryotic cells, the selective bidirectional transport of macromolecules
between the nucleus and cytoplasm occurs through the nuclear pore complex (NPC) …
between the nucleus and cytoplasm occurs through the nuclear pore complex (NPC) …
Structure and assembly of the nuclear pore complex
B Hampoelz, A Andres-Pons… - Annual review of …, 2019 - annualreviews.org
Nuclear pore complexes (NPCs) mediate nucleocytoplasmic exchange. They are
exceptionally large protein complexes that fuse the inner and outer nuclear membranes to …
exceptionally large protein complexes that fuse the inner and outer nuclear membranes to …
Transport selectivity of nuclear pores, phase separation, and membraneless organelles
HB Schmidt, D Görlich - Trends in biochemical sciences, 2016 - cell.com
Nuclear pore complexes (NPCs) provide a selective passageway for receptor-mediated
active transport between nucleus and cytoplasm, while maintaining the distinct molecular …
active transport between nucleus and cytoplasm, while maintaining the distinct molecular …
PP2A as a master regulator of the cell cycle
N Wlodarchak, Y Xing - Critical reviews in biochemistry and …, 2016 - Taylor & Francis
Abstract Protein phosphatase 2A (PP2A) plays a critical multi-faceted role in the regulation
of the cell cycle. It is known to dephosphorylate over 300 substrates involved in the cell …
of the cell cycle. It is known to dephosphorylate over 300 substrates involved in the cell …
Membrane and organelle dynamics during cell division
JG Carlton, H Jones, US Eggert - Nature Reviews Molecular Cell …, 2020 - nature.com
During division, eukaryotic cells undergo a dramatic, complex and coordinated remodelling
of their cytoskeleton and membranes. For cell division to occur, chromosomes must be …
of their cytoskeleton and membranes. For cell division to occur, chromosomes must be …