Natural killer (NK) cells, a subgroup of innate lymphoid cells, act as the first line of defense
against cancer. Although some evidence shows that NK cells can develop in secondary …

The advent of chimeric antigen receptor (CAR) T cell therapy has resulted in unprecedented
long-term clearance of relapse/refractory hematological malignancies in both pediatric and …

Natural killer (NK) cells, a unique component of the innate immune system, are inherent
killers of stressed and transformed cells. Based on their potent capacity to kill cancer cells …

Equipping cancer-fighting immune cells with chimeric antigen receptor (CAR) has gained
immense attention for cancer treatment. CAR-engineered T cells (CAR T cells) are the first …

Chimeric antigen receptor T (CAR-T) cell therapy has revolutionized the treatment of
hematological malignancies, demonstrably improving patient outcomes and prognosis …

Advanced Therapy Medicinal Products (ATMPs) based on somatic cells expanded in vitro,
with or without genetic modification, is a rapidly growing area of drug development, even …

Background Gastrointestinal (GI) cancers represent a significant health burden worldwide.
Their incidence continues to increase, and their management remains a clinical challenge …

Melanoma is among the most lethal forms of cancer, accounting for 80% of deaths despite
comprising just 5% of skin cancer cases. Treatment options remain limited due to the genetic …

Simple Summary Cell therapy has transformed oncology and drug development, yet better
model systems are needed to recapitulate the tumor immune microenvironment (TIME) …

In recent years, following the groundbreaking achievements of chimeric antigen receptor
(CAR) T cell therapy in hematological cancers, and advancements in cell engineering …