Mesenchymal stem cells (MSCs), a non-hematopoietic stem cell population first discovered
in bone marrow, are multipotent cells capable of differentiating into mature cells of several …

Skeletal muscle and bone share common embryological origins from mesodermal cell
populations and also display common growth trajectories early in life. Moreover, muscle and …

Senescence is a cellular defense mechanism that helps cells prevent acquired damage, but
chronic senescence, as in aging, can contribute to the development of age-related tissue …

Abstract Enolase 2 (ENO2) is a key glycolytic enzyme in the metabolic process of glycolysis,
but its potential function in pancreatic ductal adenocarcinoma (PDAC) is unclear. In this …

Tryptophan is an essential nutrient required to generate vitamin B3 (niacin), which is mainly
involved in energy metabolism and DNA production. Alterations in tryptophan metabolism …

Bone is a complex endocrine organ that facilitates structural support, protection to vital
organs, sites for hematopoiesis, and calcium homeostasis. The bone marrow …

Abstract Purpose of Review Osteoblasts are responsible for bone matrix production during
bone development and homeostasis. Much is known about the transcriptional regulation …

Bone marrow adipose tissue (BMAT) has been considered for several decades as a silent
bystander that fills empty space left in bone marrow following age-related decrease in …

Because of heavy energy demands to maintain bone homeostasis, the skeletal system is
closely tied to whole-body metabolism via neuronal and hormonal mediators. Glucose …

Background & Aims Intestinal microbiota modulate metabolism and associate closely with
epithelial cells in the intestine. In intestinal epithelial cells (IECs), histone deacetylase 3 …