Human coronaviruses (CoVs) are enveloped viruses with a positive-sense single-stranded RNA genome. Currently, six human CoVs have been reported including human coronavirus …
A new coronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV- 2), is the aetiological agent responsible for the 2019–2020 viral pneumonia outbreak of …
W Dai, B Zhang, XM Jiang, H Su, J Li, Y Zhao, X Xie… - Science, 2020 - science.org
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is the etiological agent responsible for the global COVID-19 (coronavirus disease 2019) outbreak. The main …
Z Jin, Y Zhao, Y Sun, B Zhang, H Wang, Y Wu… - Nature structural & …, 2020 - nature.com
The antineoplastic drug carmofur is shown to inhibit the SARS-CoV-2 main protease (Mpro). Here, the X-ray crystal structure of Mpro in complex with carmofur reveals that the carbonyl …
The newly emerged coronavirus, called SARS-CoV-2, is the causing pathogen of pandemic COVID-19. The identification of drugs to treat COVID-19 and other coronavirus diseases is …
R Banerjee, L Perera, LMV Tillekeratne - Drug Discovery Today, 2021 - Elsevier
Highlights•The SARS-CoV-2 main protease is a prime drug target.•Coronavirus main proteases share a structurally conserved substrate-binding region.•The structure and …
S Jo, S Kim, DH Shin, MS Kim - Journal of enzyme inhibition and …, 2020 - Taylor & Francis
There were severe panics caused by Severe Acute Respiratory Syndrome (SARS) and Middle-East Respiratory Syndrome-Coronavirus. Therefore, researches targeting these …
In humans, infections with the human coronavirus (HCoV) strains HCoV-229E, HCoV-OC43, HCoV-NL63 and HCoV-HKU1 usually result in mild, self-limiting upper respiratory tract …
The novel coronavirus disease, caused by severe acute respiratory coronavirus 2 (SARS- CoV-2), rapidly spreading around the world, poses a major threat to the global public health …