Immunocapture strategies in translational proteomics

C Fredolini, S Byström, E Pin, F Edfors… - Expert review of …, 2016 - Taylor & Francis
Aiming at clinical studies of human diseases, antibody-assisted assays have been applied
to biomarker discovery and toward a streamlined translation from patient profiling to assays …

Optimizing cancer immunotherapy: is it time for personalized predictive biomarkers?

M Music, I Prassas, EP Diamandis - Critical Reviews in Clinical …, 2018 - Taylor & Francis
Cancer immunotherapy, a treatment that selectively augments a patient's anti-tumor immune
response, is a breakthrough advancement in personalized medicine. A subset of cancer …

Systematic assessment of antibody selectivity in plasma based on a resource of enrichment profiles

C Fredolini, S Byström, L Sanchez-Rivera… - Scientific Reports, 2019 - nature.com
There is a strong need for procedures that enable context and application dependent
validation of antibodies. Here, we applied a magnetic bead assisted workflow and …

Discovery of a human testis-specific protein complex TEX101-DPEP3 and selection of its disrupting antibodies

C Schiza, D Korbakis, E Panteleli, K Jarvi… - Molecular & Cellular …, 2018 - ASBMB
TEX101 is a testis-specific protein expressed exclusively in male germ cells and is a
validated biomarker of male infertility. Studies in mice suggest that TEX101 is a cell-surface …

A new enzyme-linked immunosorbent assay (ELISA) for human free and bound kallikrein 9

P Filippou, D Korbakis, S Farkona, A Soosaipillai… - Clinical Proteomics, 2017 - Springer
Abstract Background Kallikrein 9 (KLK9) is a member of the human kallikrein-related
peptidases family, whose physiological role and implications in disease processes remain …

Study of kallikrein-related peptidase 6 (KLK6) and its complex with α1-antitrypsin in biological fluids

D Korbakis, A Soosaipillai… - Clinical Chemistry and …, 2017 - degruyter.com
Background: Human kallikrein-related peptidase 6 (KLK6) is a member of the kallikrein
family of serine proteases. KLK6 is synthesized as a preproenzyme, mainly in tissues of the …

[图书][B] Preclinical Evaluation of TEX101 Protein as a Male Infertility Biomarker and Identification of its Functional Interactome

C Schiza - 2017 - search.proquest.com
TEX101 is a testis-specific cell surface protein expressed exclusively in the male germ cells,
and it was previously suggested as a biomarker for the differential diagnosis of male …

Utilizing a resource of enrichment profiles in plasma for the systematic assessment of antibody selectivity

C Fredolini, S Byström, L Sanchez-Rivera, M Ioannou… - bioRxiv, 2017 - biorxiv.org
There is a strong need for procedures that enable context and application dependent
validation of antibodies. Here we describe the foundation for a resource aiding more …

[图书][B] Immuno-mass Spectrometric Identification of Predictive Biomarkers of Response and/or Toxicity to Immune Checkpoint Inhibitors

M Music - 2019 - search.proquest.com
Immune checkpoint inhibitors (ICIs) are humanized antibodies that target specific inhibitory
molecules, such as programmed cell death protein 1 (PD-1) and its ligand, PD-L1. The …

[图书][B] Investigating the Clinical Validity of CUB and Zona Pellucidalike Domain-Containing Protein 1 (CUZD1) in Malignant and Non-Malignant Human Diseases

S Farkona - 2018 - search.proquest.com
CUB and zona pellucida-like domain-containing protein 1 (CUZD1) has been previously
shown to be specifically expressed in normal pancreas and was proposed as a candidate …