A guide to the composition and functions of the extracellular matrix

NK Karamanos, AD Theocharis, Z Piperigkou… - The FEBS …, 2021 - Wiley Online Library
Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …

Emerging phagocytosis checkpoints in cancer immunotherapy

Y Liu, Y Wang, Y Yang, L Weng, Q Wu… - Signal transduction and …, 2023 - nature.com
Cancer immunotherapy, mainly including immune checkpoints-targeted therapy and the
adoptive transfer of engineered immune cells, has revolutionized the oncology landscape as …

Proteoglycan chemical diversity drives multifunctional cell regulation and therapeutics

NK Karamanos, Z Piperigkou, AD Theocharis… - Chemical …, 2018 - ACS Publications
The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …

[HTML][HTML] Revisiting the matricellular concept

JE Murphy-Ullrich, EH Sage - Matrix Biology, 2014 - Elsevier
The concept of a matricellular protein was first proposed by Paul Bornstein in the mid-1990s
to account for the non-lethal phenotypes of mice with inactivated genes encoding …

Location, location, location: how the tissue microenvironment affects inflammation in RA

CD Buckley, C Ospelt, S Gay… - Nature Reviews …, 2021 - nature.com
Current treatments for rheumatoid arthritis (RA) do not work well for a large proportion of
patients, or at all in some individuals, and cannot cure or prevent this disease. One major …

Metastasis prevention by targeting the dormant niche

CM Ghajar - Nature Reviews Cancer, 2015 - nature.com
Despite considerable advancements that shattered previously held dogmas about the
metastatic cascade, the evolution of therapies to treat metastatic disease has not kept up. In …

Extracellular matrix, a hard player in angiogenesis

M Mongiat, E Andreuzzi, G Tarticchio… - International journal of …, 2016 - mdpi.com
The extracellular matrix (ECM) is a complex network of proteins, glycoproteins,
proteoglycans, and polysaccharides. Through multiple interactions with each other and the …

Decorin interacting network: a comprehensive analysis of decorin-binding partners and their versatile functions

MA Gubbiotti, SD Vallet, S Ricard-Blum, RV Iozzo - Matrix Biology, 2016 - Elsevier
Decorin, a prototype small leucine-rich proteoglycan, regulates a vast array of cellular
processes including collagen fibrillogenesis, wound repair, angiostasis, tumor growth, and …

Pathogenesis of glaucoma: Extracellular matrix dysfunction in the trabecular meshwork‐A review

KE Keller, DM Peters - Clinical & experimental ophthalmology, 2022 - Wiley Online Library
The trabecular meshwork regulates aqueous humour outflow from the anterior chamber of
the eye. It does this by establishing a tunable outflow resistance, defined by the interplay …

The role of extracellular matrix proteins in breast cancer

A Lepucki, K Orlińska, A Mielczarek-Palacz… - Journal of Clinical …, 2022 - mdpi.com
The extracellular matrix is a structure composed of many molecules, including fibrillar (types
I, II, III, V, XI, XXIV, XXVII) and non-fibrillar collagens (mainly basement membrane collagens …