Androgen-induced gut dysbiosis disrupts glucolipid metabolism and endocrinal functions in polycystic ovary syndrome

Q Han, J Wang, W Li, ZJ Chen, Y Du - Microbiome, 2021 - Springer
Background The characteristics of polycystic ovary syndrome (PCOS), a common
reproductive endocrinal disorder, are high incidence, complicated aetiology and poor …

Therapeutic potentials of low-dose tacrolimus for aberrant endometrial features in polycystic ovary syndrome

AJH Albaghdadi, FWK Kan - International Journal of Molecular Sciences, 2021 - mdpi.com
Polycystic ovary syndrome (PCOS) is a major anovulatory infertility affecting a great
proportion of women of childbearing age and is associated with obesity, insulin resistance …

High-fat and high-sucrose diet impairs female reproduction by altering ovarian transcriptomic and metabolic signatures

C Liu, Y Dou, M Zhang, S Han, S Hu, Y Li, Z Yu… - Journal of Translational …, 2024 - Springer
Background Excessive energy intake in modern society has led to an epidemic surge in
metabolic diseases, such as obesity and type 2 diabetes, posing profound threats to …

Diacerein ameliorates induced polycystic ovary in female rats via modulation of inflammasome/caspase1/IL1β and Bax/Bcl2 pathways

MMM Refaie, M El-Hussieny… - … Archives of Pharmacology, 2022 - Springer
Polycystic ovary syndrome (PCOS) is a very common gynecological disease during
childbearing period and markedly affects female fertility. Until now, there are no studies …

Untargeted Metabolomics Revealed Potential Biomarkers of Small Yellow Follicles of Chickens during Sexual Maturation

J Zhao, H Pan, W Zhao, W Li, H Li, Z Tian, D Meng… - Metabolites, 2023 - mdpi.com
Sexual maturation provides economically important traits in poultry production. Research on
the initiation mechanism of sexual maturity is of great significance for breeding high-yield …

Effects of treatment with clinically relevant valproate, carbamazepine, oxcarbazepine, topiramate, lamotrigine and levetiracetam on ovarian folliculogenesis in young …

A Cansu, SG Gurgen, YN Demirhan, PO Kart… - Epilepsy Research, 2022 - Elsevier
Aim To determine the effects of valproate (VPA), carbamazepine (CBZ), oxcarbazepine
(OXC), topiramate (TPM), lamotrigine (LTG), and levetiracetam (LEV) on ovarian …

Heme oxygenase 2 genetic variants alter hormonal and metabolic traits in polycystic ovary syndrome

X Zhang, S Li, H Liu, H Bai, Q Liu… - Endocrine …, 2024 - ec.bioscientifica.com
Oxidative stress and metabolic disorders are involved in the pathogenesis of polycystic
ovary syndrome (PCOS). Heme oxygenase 2 (HMOX2) plays a critical role in preserving …

Cardioprotective effect of hemin in isoprenaline‐induced myocardial infarction: role of ATP‐sensitive potassium channel and endothelial nitric oxide synthase

MMM Refaie, RA Rifaai, AMA Bayoumi… - Fundamental & …, 2020 - Wiley Online Library
Ischemic heart disease is a common cardiac health problem. Despite the significant
advances in prevention and treatment of this disorder, its incidences and complications are …

Very low dose spironolactone protects experimentally-induced polycystic ovarian syndrome from insulin-resistant metabolic disturbances by suppressing elevated …

OA Adeyanju, TO Falodun, OA Fabunmi… - Chemico-Biological …, 2019 - Elsevier
Polycystic ovarian syndrome (PCOS) is the most common endocrinological disorder in
women of reproductive age and hyperandrogenism is a prominent feature of PCOS resulting …

Genetic basis of metabolism and inflammation in PCOS

Y Pang, Y Zhao, J Qiao - Human Reproductive and Prenatal Genetics, 2023 - Elsevier
PCOS is a complex and heterogeneous disorder characterized by hyperandrogenemia,
insulin resistance, and chronic anovulation affecting 6%–10% women of childbearing age …