Systemic therapy often results in the reduction of tumor size but rarely succeeds in
eradicating all cancer cells. Drug efflux, persistence of cancer stem cells (CSCs), epithelial …

Aims: To develop a novel nanomedicine approach for the treatment of multidrug-resistant
(MDR) cancer by combining an anticancer drug and suppressors of cellular resistance …

Mechanical factors in the tumor microenvironment play an important role in response to a
variety of cellular activities in cancer cells. Here, we utilized polyacrylamide hydrogels with …

To compare the influence of different characteristics of nanocarriers on the efficacy of
chemotherapy and imaging, we designed, characterized, and evaluated three widely used …

Taxanes are one type of the most extensively used chemotherapeutic agents to treat
cancers. However, their clinical use is severely limited by intrinsic and acquired resistance …

OBJECTIVE: The aims of the study were to evaluate the ability of metformin to induce
apoptosis in epithelial ovarian cancer cell lines and to identify the pathways involved in this …

Many studies involving patients with cisplatin-resistant ovarian cancer have shown that AKT
activation leads to inhibition of apoptosis. The aim of this study was to examine the potential …

Background Ovarian cancer remains the most fatal gynecological malignancy. Current
therapeutic options are limited due to late diagnosis in the majority of the cases, metastatic …

Background: P53, EGFR and HER-2/neu are the most frequently studied molecular
biological parameters in epithelial ovarian cancer, but their prognostic impact is still …

Traditional clinicopathological features do not predict which patients will develop
chemotherapy resistance. The TP53 gene is frequently altered in ovarian cancer but its …