Bioengineering approaches to treat the failing heart: from cell biology to 3D printing

M Yadid, H Oved, E Silberman, T Dvir - Nature Reviews Cardiology, 2022 - nature.com
Successfully engineering a functional, human, myocardial pump would represent a
therapeutic alternative for the millions of patients with end-stage heart disease and provide …

Myocardial mesostructure and mesofunction

AJ Wilson, GB Sands, IJ LeGrice… - American Journal of …, 2022 - journals.physiology.org
The complex and highly organized structural arrangement of some five billion
cardiomyocytes directs the coordinated electrical activity and mechanical contraction of the …

Multiscale Anisotropic Scaffold Integrating 3D Printing and Electrospinning Techniques as a Heart‐on‐a‐Chip Platform for Evaluating Drug‐Induced Cardiotoxicity

S Liu, Z Wang, X Chen, M Han, J Xu, T Li… - Advanced …, 2023 - Wiley Online Library
Cardiac safety assessments are significant in drug discovery, as drug‐induced cardiotoxicity
(DIC) is the primary cause of drug attrition. Despite heart‐on‐a‐chip (HoC) technology …

Quinapril treatment curtails decline of global longitudinal strain and mechanical function in hypertensive rats

AJ Wilson, GB Sands, VY Wang, B Pontre… - Journal of …, 2023 - journals.lww.com
Background: Left ventricular (LV) global longitudinal strain (GLS) has been proposed as an
early imaging biomarker of cardiac mechanical dysfunction. Objective: To assess the impact …

Ventricular helix angle trends and long-range connectivity

AJ Wilson, QJ Han, LE Perotti, DB Ennis - International Conference on …, 2023 - Springer
Abstract Porcine hearts (N= 14) underwent ex vivo diffusion tensor imaging (DTI) at 3T. DTI
analysis showed regional differences in helix angle (HA) range. The HA range in the …

Analysis of location-dependent cardiomyocyte branching

AJ Wilson, GB Sands, DB Ennis - … on Functional Imaging and Modeling of …, 2021 - Springer
Cardiomyocytes branch and interconnect with one another, providing important redundancy
for propagation of electro-chemical signals. Despite this, cardiomyocyte branching structure …

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D Trend, L Mujezin¹, A Salkić… - 32nd Scientific-Expert …, 2023 - books.google.com
Nutrition that is based on mostly consuming plant origin food, also known as plant-based
diet, generates multiple forms of dietary patterns, which in common have lower …

Restored Torsion and Longitudinal Strain in ACE Inhibitor Treated Hypertension

A Wilson, GB Sands, VY Wang, B Pontre, DB Ennis… - archive.ismrm.org
Tagged CMR was used to measure torsion and longitudinal strain in a rodent model of
hypertensive heart disease. Long-term ACE inhibitor treatment restored ejection fraction …