Human papillomaviruses; epithelial tropisms, and the development of neoplasia

N Egawa, K Egawa, H Griffin, J Doorbar - Viruses, 2015 - mdpi.com
Papillomaviruses have evolved over many millions of years to propagate themselves at
specific epithelial niches in a range of different host species. This has led to the great …

Functional roles of E6 and E7 oncoproteins in HPV-induced malignancies at diverse anatomical sites

V Tomaić - Cancers, 2016 - mdpi.com
Approximately 200 human papillomaviruses (HPVs) infect human epithelial cells, of which
the alpha and beta types have been the most extensively studied. Alpha HPV types mainly …

Papillomaviruses and cancer: Commonalities and differences in HPV carcinogenesis at different sites of the body

N Egawa - International Journal of Clinical Oncology, 2023 - Springer
Human papillomavirus (HPV) is associated with 5% of all cancers globally at a range of
body sites, including cervix, anus, penis, vagina, vulva, and oropharynx. These cancers …

Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression

JA Smith, EA White, ME Sowa… - Proceedings of the …, 2010 - National Acad Sciences
An essential step in the pathogenesis of human papillomavirus (HPV)–associated cancers is
the dysregulated expression of the viral oncogenes. The papillomavirus E2 protein can …

[HTML][HTML] Regulatory elements in the viral genome

HU Bernard - Virology, 2013 - Elsevier
The small DNA genomes of papillomaviruses contain a surprisingly large number of
regulatory or cis-responsive elements, which regulate replication and transcription of the …

Estrogen attenuates the growth of human papillomavirus-positive epithelial cells

ML Bristol, CD James, X Wang, CT Fontan, IM Morgan - Msphere, 2020 - Am Soc Microbiol
Human papillomaviruses (HPVs) are small, double-stranded DNA viruses that are significant
risk factors in the development of cancer, and HPV accounts for approximately 5% of all …

Identification of target cells of human papillomavirus 18 using squamocolumnar junction organoids

Y Toyohara, A Taguchi, Y Ishii, D Yoshimoto… - Cancer …, 2024 - Wiley Online Library
Abstract Human papillomavirus 18 (HPV18) is a highly malignant HPV genotype among
high‐risk HPVs, characterized by the difficulty of detecting it in precancerous lesions and its …

Comparative Analysis of Alpha and Beta HPV E6 Oncoproteins: Insights into Functional Distinctions and Divergent Mechanisms of Pathogenesis

J Skelin, V Tomaić - Viruses, 2023 - mdpi.com
Human papillomaviruses (HPVs) represent a diverse group of DNA viruses that infect
epithelial cells of mucosal and cutaneous tissues, leading to a wide spectrum of clinical …

NCoR1 mediates papillomavirus E8^ E2C transcriptional repression

MLC Powell, JA Smith, ME Sowa, JW Harper… - Journal of …, 2010 - Am Soc Microbiol
The papillomavirus E2 open reading frame encodes the full-length E2 protein as well as an
alternatively spliced product called E8^ E2C. E8^ E2C has been best studied for the high …

Development of Antibodies against HPV-6 and HPV-11 for the Study of Laryngeal Papilloma

T Ikegami, N Kise, H Kinjyo, S Kondo, M Suzuki… - Viruses, 2021 - mdpi.com
Laryngeal papilloma (LP), which is associated with infection by human papillomavirus (HPV)-
6 or-11, displays aggressive growth. The precise molecular mechanism underlying the …