miRNAs as potential game-changers in bone diseases: Future medicinal and clinical Uses

AS Doghish, MS Elballal, O Elazazy… - … -Research and Practice, 2023 - Elsevier
Abstract MicroRNAs (miRNAs), short, highly conserved non-coding RNA, influence gene
expression by sequential mechanisms such as mRNA breakdown or translational …

Metastasis organotropism: redefining the congenial soil

Y Gao, I Bado, H Wang, W Zhang, JM Rosen… - Developmental cell, 2019 - cell.com
Metastasis is the most devastating stage of cancer progression and causes the majority of
cancer-related deaths. Clinical observations suggest that most cancers metastasize to …

[HTML][HTML] Breast cancer exosomes contribute to pre-metastatic niche formation and promote bone metastasis of tumor cells

X Yuan, N Qian, S Ling, Y Li, W Sun, J Li, R Du… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: Breast cancer preferentially develops osteolytic bone metastasis, which makes
patients suffer from pain, fractures and spinal cord compression. Accumulating evidences …

MAPK1/3 kinase-dependent ULK1 degradation attenuates mitophagy and promotes breast cancer bone metastasis

R Deng, HL Zhang, JH Huang, RZ Cai, Y Wang… - Autophagy, 2021 - Taylor & Francis
The function of mitophagy in cancer is controversial. ULK1 is critical for induction of
macroautophagy/autophagy and has a more specific role in mitophagy in response to …

Multi-stage mechanisms of tumor metastasis and therapeutic strategies

Z Liu, J Chen, Y Ren, S Liu, Y Ba, A Zuo… - … and Targeted Therapy, 2024 - nature.com
The cascade of metastasis in tumor cells, exhibiting organ-specific tendencies, may occur at
numerous phases of the disease and progress under intense evolutionary pressures. Organ …

EZH2 engages TGFβ signaling to promote breast cancer bone metastasis via integrin β1-FAK activation

L Zhang, J Qu, Y Qi, Y Duan, YW Huang, Z Zhou… - Nature …, 2022 - nature.com
Abstract Bone metastases occur in 50–70% of patients with late-stage breast cancers and
effective therapies are needed. The expression of enhancer of zeste homolog 2 (EZH2) is …

Evolving cancer–niche interactions and therapeutic targets during bone metastasis

RL Satcher, XHF Zhang - Nature Reviews Cancer, 2022 - nature.com
Many cancer types metastasize to bone. This propensity may be a product of genetic traits of
the primary tumour in some cancers. Upon arrival, cancer cells establish interactions with …

[HTML][HTML] Black Mn-containing layered double hydroxide coated magnesium alloy for osteosarcoma therapy, bacteria killing, and bone regeneration

D Zhang, S Cheng, J Tan, J Xie, Y Zhang, S Chen… - Bioactive Materials, 2022 - Elsevier
Osteosarcoma (OS) tissue resection with distinctive bactericidal activity, followed by
regeneration of bone defects, is a highly demanded clinical treatment. Biodegradable Mg …

RUNX2 recruits the NuRD (MTA1)/CRL4B complex to promote breast cancer progression and bone metastasis

X Yin, X Teng, T Ma, T Yang, J Zhang, M Huo… - Cell Death & …, 2022 - nature.com
Runt-related transcription factor 2 (RUNX2) is an osteogenesis-related transcription factor
that has emerged as a prominent transcription repressing factor in carcinogenesis. However …

Characteristics of pre-metastatic niche: the landscape of molecular and cellular pathways

H Wang, J Pan, L Barsky, JC Jacob, Y Zheng… - Molecular …, 2021 - Springer
Metastasis is a major contributor to cancer-associated deaths. It involves complex
interactions between primary tumorigenic sites and future metastatic sites. Accumulation …